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Two-year follow-up of pulmonary arterial hypertension patients treated with sildenafil

Franchi, Sonia Meiken ; Barreto, Alessandra Costa ; Cícero, Cristina ; Castro, Claudia Regina Pinheiro ; Ribeiro, Zilma Verçosa de Sá ; Lopes, Antonio Augusto

Arquivos brasileiros de cardiologia, 2010-05, Vol.94 (5), p.671-677 [Periódico revisado por pares]

Brazil

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Título:
Two-year follow-up of pulmonary arterial hypertension patients treated with sildenafil
Autor: Franchi, Sonia Meiken ; Barreto, Alessandra Costa ; Cícero, Cristina ; Castro, Claudia Regina Pinheiro ; Ribeiro, Zilma Verçosa de Sá ; Lopes, Antonio Augusto
Assuntos: Adolescent ; Adult ; Child ; Dyspnea - physiopathology ; Exercise Test - drug effects ; Female ; Follow-Up Studies ; Humans ; Hypertension, Pulmonary - drug therapy ; Hypertension, Pulmonary - physiopathology ; Male ; Middle Aged ; Oxygen Consumption - physiology ; Phosphodiesterase 5 Inhibitors - therapeutic use ; Piperazines - therapeutic use ; Prospective Studies ; Purines - therapeutic use ; Sildenafil Citrate ; Statistics, Nonparametric ; Sulfones - therapeutic use ; Time Factors ; Treatment Outcome ; Young Adult
É parte de: Arquivos brasileiros de cardiologia, 2010-05, Vol.94 (5), p.671-677
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
Descrição: The long-term effects of drugs developed for the control of pulmonary arterial hypertension (PAH) are little known, since multicenter studies usually last 12 to 16 weeks. To evaluate the two-year outcome of PAH patients receiving monotherapy with sildenafil (a phosphodiesterase-5 inhibitor), with regard to their functional capacity. Twenty four patients (ages between 8 and 54 years) with idiopathic PAH (IPAH, n = 9) or congenital heart disease-associated PAH (CHD-PAH, n = 15) were treated with sildenafil for two years, with daily oral doses ranging from 60 to 225 mg (tid). Physical capacity was assessed by the distance walked in the 6-minute walk test (DW6M) and by the degree of dyspnea at the end of the walk (Borg scale); peripheral oxygen saturation was also recorded (SpO(2)6M, pulse oximetry). In the 18 patients who completed the two-year follow-up, there was a progressive and sustained increase in DW6M, both in the IPAH group (from 239 +/- 160 m to 471 +/- 66 m, p = 0.0076) and in the CHD-PAH group (from 361 +/- 144 m to 445 +/- 96 m, p = 0.0031), with improvement of dyspnea at the end of the walk (p<0.05 for both groups). No decrease in SpO(2)6M was observed in the groups; in patients with CHD-PAH, in particular, SpO(2)6M went from 77 +/- 20% to 79 +/- 16% (p = 0.5248). Five deaths occurred (three in the IPAH group) and one patient was lost to follow-up during the study period. In a two-year follow-up, sildenafil proved useful in the control of the functional status of PAH patients, with significant improvement in both groups considered.
Editor: Brazil
Idioma: Português

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Two-year follow-up of pulmonary arterial hypertension patients treated with sildenafil

Franchi, Sonia Meiken ; Barreto, Alessandra Costa ; Cícero, Cristina ; Castro, Claudia Regina Pinheiro ; Ribeiro, Zilma Verçosa de Sá ; Lopes, Antonio Augusto

Brazil

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