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Nitrate-rich beet juice intake on cardiovascular performance in response to exercise in postmenopausal women with arterial hypertension: study protocol for a randomized controlled trial

Benjamim, Cicero Jonas R ; Sousa, Yaritza Brito Alves ; Porto, Andrey Alves ; de Moraes Pontes, Yasmim Mota ; Tavares, Simone Sakagute ; da Silva Rodrigues, Guilherme ; da Silva, Leonardo Santos Lopes ; da Silva Goncalves, Leonardo ; Guimaraes, Carolina Scoqui ; Rebelo, Macário Arosti ; da Silva Sobrinho, Andressa Crystine ; Tanus-Santos, Jose E ; Valenti, Vitor Engracia ; Gualano, Bruno ; Bueno Júnior, Carlos Roberto

Current controlled trials in cardiovascular medicine, 2023-02, Vol.24 (1), p.94-94, Article 94 [Periódico revisado por pares]

England: BioMed Central Ltd

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Nitrate-rich beet juice intake on cardiovascular performance in response to exercise in postmenopausal women with arterial hypertension: study protocol for a randomized controlled trial
Autor: Benjamim, Cicero Jonas R ; Sousa, Yaritza Brito Alves ; Porto, Andrey Alves ; de Moraes Pontes, Yasmim Mota ; Tavares, Simone Sakagute ; da Silva Rodrigues, Guilherme ; da Silva, Leonardo Santos Lopes ; da Silva Goncalves, Leonardo ; Guimaraes, Carolina Scoqui ; Rebelo, Macário Arosti ; da Silva Sobrinho, Andressa Crystine ; Tanus-Santos, Jose E ; Valenti, Vitor Engracia ; Gualano, Bruno ; Bueno Júnior, Carlos Roberto
Assuntos: Aerobics ; Beets ; Beta vulgaris ; Blood pressure ; Cardiovascular physiological phenomena ; Cardiovascular System ; Care and treatment ; Chemical properties ; Clinical trials ; Cross-Over Studies ; Demographic aspects ; Diagnosis ; Dietary Supplements ; Dosage and administration ; Double-Blind Method ; Drug dosages ; Enzymes ; Exercise ; Exercise - physiology ; Female ; Health aspects ; Heart rate ; Humans ; Hypertension ; Internal medicine ; Laboratories ; Medical schools ; Medicine ; Nervous system ; Nitrate ; Nitrates ; Nitrates - analysis ; Nitrates - therapeutic use ; Nitric oxide ; Nitrites - analysis ; Nursing schools ; Nutrition research ; Oxidative stress ; Physical education ; Physical fitness ; Physiological aspects ; Physiology ; Post-menopause ; Postmenopausal women ; Postmenopause ; Randomized Controlled Trials as Topic ; Sports nutritional sciences ; Study Protocol ; Testing
É parte de: Current controlled trials in cardiovascular medicine, 2023-02, Vol.24 (1), p.94-94, Article 94
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Descrição: There is no evidence of the use of beetroot juice with a previously recommended dose of nitrate (NO3) (> 300 mg) on the cardiovascular performance during and recovery following exercise in postmenopausal women with systemic arterial hypertension (SAH). We will investigate the effects of beetroot juice rich in NO3 acutely (800 mg) and during a week with daily doses (400 mg) on blood pressure, heart rate (HR), cardiac autonomic control, endothelial function, inflammatory, hormonal, and stress biomarkers oxidative stress and enzymes involved in nitric oxide synthesis and mitochondrial regulation, under resting conditions, as well as mediated by submaximal aerobic exercise sessions. Through a randomized, crossover, triple-blind, placebo-controlled clinical trial, 25 physically inactive women with SAH will undergo an acute and 1-week trial, each with two intervention protocols: (1) placebo and (2) beetroot, in which will ingest beet juice with or without NO3 in its composition with a 7-day washout interval. On collection days, exercise will be performed on a treadmill for 40 min at a speed corresponding to 65-70% of VO2peak. The collection of variables (cardiovascular, autonomic, and blood samples for molecular analyses) of the study will take place at rest (135 min after ingestion of the intervention), during exercise (40 min), and in the effort recovery stage (during 60 min) based on previously validated protocols. The collections were arranged so that the measurement of one variable does not interfere with the other and that they have adequate intervals between them. The results of this research may help in the real understanding of the nutritional compounds capable of generating safety to the cardiovascular system during physical exercise, especially for women who are aging and who have cardiovascular limitations (e.g., arterial hypertension) to perform physical exercise. Therefore, our results will be able to help specific nutritional recommendations to optimize cardiovascular health. ClinicalTrials.gov NCT05384340. Registered on May 20, 2022.
Editor: England: BioMed Central Ltd
Idioma: Inglês

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Nitrate-rich beet juice intake on cardiovascular performance in response to exercise in postmenopausal women with arterial hypertension: study protocol for a randomized controlled trial

England: BioMed Central Ltd

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