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Analgesic and anti-inflammatory activity of a crude root extract of Pfaffia glomerata (Spreng) Pedersen

Neto, A.G. ; Costa, J.M.L.C. ; Belati, C.C. ; Vinhólis, A.H.C. ; Possebom, L.S. ; Da Silva Filho, A.A. ; Cunha, W.R. ; Carvalho, J.C.T. ; Bastos, J.K. ; e Silva, M.L.A.

Journal of ethnopharmacology, 2005-01, Vol.96 (1), p.87-91 [Periódico revisado por pares]

Shannon: Elsevier Ireland Ltd

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Título:
Analgesic and anti-inflammatory activity of a crude root extract of Pfaffia glomerata (Spreng) Pedersen
Autor: Neto, A.G. ; Costa, J.M.L.C. ; Belati, C.C. ; Vinhólis, A.H.C. ; Possebom, L.S. ; Da Silva Filho, A.A. ; Cunha, W.R. ; Carvalho, J.C.T. ; Bastos, J.K. ; e Silva, M.L.A.
Assuntos: Amaranthaceae ; Analgesic activity ; analgesic effect ; Analgesics - chemistry ; Analgesics - therapeutic use ; Animals ; Anti-inflammatory activity ; Anti-Inflammatory Agents - chemistry ; Anti-Inflammatory Agents - therapeutic use ; Biological and medical sciences ; Brazilian ginseng ; Carrageenan ; Dose-Response Relationship, Drug ; Edema - chemically induced ; Edema - drug therapy ; General pharmacology ; Male ; Medical sciences ; medicinal plants ; Mice ; Pain Measurement ; paratudo ; Pfaffia glomerata ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Phytotherapy ; plant extracts ; Plant Extracts - administration & dosage ; Plant Extracts - chemistry ; Plant Extracts - therapeutic use ; Plant Roots - chemistry ; Rats ; Rats, Wistar ; roots ; traditional medicine
É parte de: Journal of ethnopharmacology, 2005-01, Vol.96 (1), p.87-91
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: The anti-inflammatory and antinociceptive effects of the crude hydroalcoholic extract (PE) of Pfaffia glomerata roots was assessed in the carrageenan-induced rat paw edema at the doses of 100, 200 and 300 mg/kg, using different animal models. An anti-inflammatory dose effect response correlation of r = 0.997 and Y = 11.67 x + 0.02 was found. At the same doses, the extract-inhibited acetic acid-induced writhing in mice, but no dose response correlation was found. Oral administration of 100 mg/kg of PE and 0.5 mg/kg of dexamethazone inhibited by 29 and 61%, the granulomatous tissue formation ( p > 0.05), respectively. These results indicate the potential of this plant extract to treat chronic inflammation. At the assayed doses no significant activity was found in the hot plate test, as well as in the cell migration-induced by carrageenan.
Editor: Shannon: Elsevier Ireland Ltd
Idioma: Inglês

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Analgesic and anti-inflammatory activity of a crude root extract of Pfaffia glomerata (Spreng) Pedersen

Neto, A.G. ; Costa, J.M.L.C. ; Belati, C.C. ; Vinhólis, A.H.C. ; Possebom, L.S. ; Da Silva Filho, A.A. ; Cunha, W.R. ; Carvalho, J.C.T. ; Bastos, J.K. ; e Silva, M.L.A.

Shannon: Elsevier Ireland Ltd

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