skip to main content
Idioma:

Partial Coated Stem Cells with Bioinspired Silica as New Generation of Cellular Hybrid Materials

Maciel, Marta M. ; Correia, Tiago R. ; Gaspar, Vítor M. ; Rodrigues, João M. M. ; Choi, Insung S. ; Mano, João F.

Advanced functional materials, 2021-07, Vol.31 (29), p.n/a [Periódico revisado por pares]

Hoboken: Wiley Subscription Services, Inc

Texto completo disponível

Citações Citado por
  • Título:
    Partial Coated Stem Cells with Bioinspired Silica as New Generation of Cellular Hybrid Materials
  • Autor: Maciel, Marta M. ; Correia, Tiago R. ; Gaspar, Vítor M. ; Rodrigues, João M. M. ; Choi, Insung S. ; Mano, João F.
  • Assuntos: advanced cell‐material interactions ; Biocompatibility ; Biomimetics ; cell partial coatings ; cell‐based materials ; Chitosan ; Materials science ; Microorganisms ; organic–inorganic hybrid composites ; Priming ; Quaternary ammonium salts ; Silicon dioxide ; Sol-gel processes ; Stem cells ; Survival ; Tissue engineering
  • É parte de: Advanced functional materials, 2021-07, Vol.31 (29), p.n/a
  • Descrição: The manipulation of cell surfaces in anchorage‐dependent cells can help overcome difficulties presented during cell handling and application. Silica‐based protective mechanisms existing in free‐floating microorganisms may be used as inspiration for sustaining human cell survival in suspension. Gathering on this, herein human adipose‐derived mesenchymal stem cells (hASCs) are partially coated with a hard silica layer that operates as a supporting platform for individual cells in suspension. Inspired by the organic templates involved in biosilicification, a novel chitosan (CHT) derivative displaying fully natural quaternary amine moieties is synthetized via a rapid, one‐pot strategy. Silicification is promoted on individual hASCs surfaces via a two‐step process: a priming step onto previously adhered cell with this CHT derivative, followed by a biocompatible sol–gel process. hASCs holding a silica backpack exhibit enhanced cell survival in suspension conditions and can spread and acquire a more adherent phenotype. This new protocol for cell‐surface modification also provides a new generation of hybrid materials with functionalization of the silica backpack, which can be applied to different areas such as tissue engineering, biosensing, drug delivery, and targeted cell‐based therapies. Silica partial coatings on the surface of human adipose‐derived mesenchymal stem cells are a novel and disruptive concept. The formation of these tough supports improves single‐cell survival and functionality in suspension environments. Also, these hybrid cells can be functionalized through silica with different molecules opening the possibility for various applications from sensing to drug delivery and microtissue formation.
  • Editor: Hoboken: Wiley Subscription Services, Inc
  • Idioma: Inglês
Voltar para lista de resultados

  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

Buscando em bases de dados remotas. Favor aguardar.