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Ageing, metabolism and cardiovascular disease

Costantino, Sarah ; Paneni, Francesco ; Cosentino, Francesco

The Journal of physiology, 2016-04, Vol.594 (8), p.2061-2073 [Periódico revisado por pares]

England: Wiley Subscription Services, Inc

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Título:
Ageing, metabolism and cardiovascular disease
Autor: Costantino, Sarah ; Paneni, Francesco ; Cosentino, Francesco
Assuntos: Ageing and Consequences for Longevity ; Aging ; Aging - metabolism ; Aging - pathology ; Aging and Degeneration ; Animals ; Cardiovascular Conditions, Disorders and Treatments ; Cardiovascular disease ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - metabolism ; Cardiovascular Diseases - physiopathology ; Cardiovascular System - growth & development ; Cardiovascular System - metabolism ; Gene Expression Regulation, Developmental ; Homeostasis ; Humans ; Medicin och hälsovetenskap ; Metabolism ; Metabolism and Regulation ; Signal Transduction ; Topical Review
É parte de: The Journal of physiology, 2016-04, Vol.594 (8), p.2061-2073
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Descrição: Age is one of the major risk factors associated with cardiovascular disease (CVD). About one‐fifth of the world population will be aged 65 or older by 2030, with an exponential increase in CVD prevalence. It is well established that environmental factors (overnutrition, smoking, pollution, sedentary lifestyles) may lead to premature defects in mitochondrial functionality, insulin signalling, endothelial homeostasis and redox balance, fostering early senescent features. Over the last few years, molecular investigations have unveiled common signalling networks which may link the ageing process with deterioration of cardiovascular homeostasis and metabolic disturbances, namely insulin resistance. These different processes seem to be highly interconnected and their interplay may favour adverse vascular and cardiac phenotypes responsible for myocardial infarction, stroke and heart failure. In the present review, we carefully describe novel molecular cues underpinning ageing, metabolism and CVD. In particular, we describe a dynamic interplay between emerging pathways such as FOXOs, AMPK, SIRT1, p66Shc, JunD and NF‐kB. This overview will provide the background for attractive molecular targets to prevent age‐driven pathology in the vasculature and the heart. Diagram showing the interconnection between ageing, metabolic impairment and cardiovascular disease. An array of molecular events affects cellular homeostasis during the life course, thus fostering accumulation free radicals, mitochondrial damage as well as maladaptive insulin signalling. These processes, in turn, favour the development of cardiometabolic states such as obesity, type 2 diabetes and adverse cardiovascular phenotypes.
Editor: England: Wiley Subscription Services, Inc
Idioma: Inglês

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Ageing, metabolism and cardiovascular disease

Costantino, Sarah ; Paneni, Francesco ; Cosentino, Francesco

England: Wiley Subscription Services, Inc

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