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EFMrep: An extension of EuroForMix for improved combination of STR DNA mixture profiles

Bleka, Øyvind ; Prieto, Lourdes ; Gill, Peter

Forensic science international : genetics, 2022-11, Vol.61, p.102771-102771, Article 102771 [Periódico revisado por pares]

Elsevier B.V

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  • Título:
    EFMrep: An extension of EuroForMix for improved combination of STR DNA mixture profiles
  • Autor: Bleka, Øyvind ; Prieto, Lourdes ; Gill, Peter
  • Assuntos: CE-STR ; likelihood ratio deconvolution ; multiplexes ; probabilistic genotyping software
  • É parte de: Forensic science international : genetics, 2022-11, Vol.61, p.102771-102771, Article 102771
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: The EuroForMix model has been extended to create a new open-source software, called EFMrep which enables the combination of STR DNA mixture samples from, different multiplexes. In addition to calculating combined likelihood ratios and carrying, out deconvolution, the software also includes the capability to specify related unknown, individuals. A graphical user interface has been implemented to ease the analysis for, practitioners in real case work. The effect of combining multiple samples based on the, PROVEDIt dataset was investigated, either from the same or different multiplexes. The, information gain increases when more samples are combined. A head-to-head, comparison against EuroForMix shows the benefit of a more general model., Guidelines are provided. A real case example was used to demonstrate how EFMrep, could be used to combine multiple samples when a proposition includes kinship. •EFMrep is a new software which extends the EuroForMix model.•Possible to combine samples from different multiplexes.•Increased information gain when samples are combined.•Demonstration of real case with kinship.
  • Editor: Elsevier B.V
  • Idioma: Inglês;Norueguês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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