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Butyrylcholinesterase: K variant, plasma activity, molecular forms and rivastigmine treatment in Alzheimer's disease in a Southern Brazilian population

Bono, G.F. ; Simão-Silva, D.P. ; Batistela, M.S. ; Josviak, N.D. ; Dias, P.F.R. ; Nascimento, G.A. ; Souza, R.L.R. ; Piovezan, M.R. ; Souza, R.K.M. ; Furtado-Alle, L.

Neurochemistry international, 2015-02, Vol.81, p.57-62 [Periódico revisado por pares]

England: Elsevier Ltd

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  • Título:
    Butyrylcholinesterase: K variant, plasma activity, molecular forms and rivastigmine treatment in Alzheimer's disease in a Southern Brazilian population
  • Autor: Bono, G.F. ; Simão-Silva, D.P. ; Batistela, M.S. ; Josviak, N.D. ; Dias, P.F.R. ; Nascimento, G.A. ; Souza, R.L.R. ; Piovezan, M.R. ; Souza, R.K.M. ; Furtado-Alle, L.
  • Assuntos: Alzheimer Disease - blood ; Alzheimer Disease - drug therapy ; Alzheimer Disease - enzymology ; Alzheimer's disease ; BChE molecular forms ; BChE-K ; Brazil ; Butyrylcholinesterase ; Butyrylcholinesterase - blood ; Butyrylcholinesterase - chemistry ; Case-Control Studies ; CHE2 locus ; Cholinesterase Inhibitors - therapeutic use ; Disease Progression ; Humans ; Rivastigmine - therapeutic use
  • É parte de: Neurochemistry international, 2015-02, Vol.81, p.57-62
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: •We verify the relationship between BChE enzyme and Alzheimer's disease (AD).•Total BChE activity was significantly lower in AD patients than in controls.•The BChE activity reduction is associated directly with AD progression.•Rivastigmine treatment has a stronger effect on BChE activity in the AD moderate patient group.•We suggest a future perspective of BChE as a plasmatic secondary marker for AD. Alzheimer's disease (AD) is a neurodegenerative disorder in which there is a decline of cholinergic function. The symptomatic AD treatment involves the use of ChEIs (cholinesterase inhibitors) as rivastigimine, a dual inhibitor. The human butyrylcholinesterase (BChE) is an enzyme that has specific roles in cholinergic neurotransmission and it has been associated with AD. In the serum, BChE is found in four main molecular forms: G1 (monomer); G1-ALB (monomer linked to albumin); G2 (dimer); and G4 (tetramer). The interaction between the products of BCHE gene and CHE2 locus results in CHE2 C5+ and CHE2 C5- phenotypes. CHE2 C5+ phenotype and BChE-K are factors that influence on BChE activity. This work aimed to verify the proportions of BChE molecular forms, total and relative activity in 139 AD patients and 139 elderly controls, taking into account K variant, CHE2 locus, rivastigmine treatment and clinical dementia rating (CDR) of AD patients. Phenotypic frequencies of CHE2 C5+ and frequency of the carriers of the K allele were similar between groups. Total BChE activity in plasma was significantly lower in AD patients than in elderly controls. Furthermore, we found that reduction on plasma BChE activity is associated directly with AD progression in AD patients and that rivastigmine treatment has a stronger effect on BChE activity within the CDR2 group. The reduction in BChE activity did not occur proportionally in all molecular forms. Multiple regression analysis results confirmed that AD acts as the main factor in plasma BChE activity reduction and that severe stages are related with an even greater reduction. These findings suggest that the reduction of total plasma BChE and relative BChE molecular forms activity in AD patients is probably associated with a feedback mechanism and provides a future perspective of using this enzyme as a possible plasmatic secondary marker for AD.
  • Editor: England: Elsevier Ltd
  • Idioma: Inglês
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