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Genetic history of an archaic hominin group from Denisova Cave in Siberia

Reich, David ; Viola, Bence ; Pääbo, Svante ; Green, Richard E ; Kircher, Martin ; Krause, Johannes ; Patterson, Nick ; Durand, Eric Y ; Briggs, Adrian W ; Stenzel, Udo ; Johnson, Philip L. F ; Maricic, Tomislav ; Good, Jeffrey M ; Marques-Bonet, Tomas ; Alkan, Can ; Fu, Qiaomei ; Mallick, Swapan ; Li, Heng ; Meyer, Matthias ; Eichler, Evan E ; Stoneking, Mark ; Richards, Michael ; Talamo, Sahra ; Shunkov, Michael V ; Derevianko, Anatoli P ; Hublin, Jean-Jacques ; Kelso, Janet ; Slatkin, Montgomery

Nature (London), 2010-12, Vol.468 (7327), p.1053-1060 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
Genetic history of an archaic hominin group from Denisova Cave in Siberia
Autor: Reich, David ; Viola, Bence ; Pääbo, Svante ; Green, Richard E ; Kircher, Martin ; Krause, Johannes ; Patterson, Nick ; Durand, Eric Y ; Briggs, Adrian W ; Stenzel, Udo ; Johnson, Philip L. F ; Maricic, Tomislav ; Good, Jeffrey M ; Marques-Bonet, Tomas ; Alkan, Can ; Fu, Qiaomei ; Mallick, Swapan ; Li, Heng ; Meyer, Matthias ; Eichler, Evan E ; Stoneking, Mark ; Richards, Michael ; Talamo, Sahra ; Shunkov, Michael V ; Derevianko, Anatoli P ; Hublin, Jean-Jacques ; Kelso, Janet ; Slatkin, Montgomery
Assuntos: ADN mitocondrial ; Animals ; Anthropology ; Asia ; DNA, Mitochondrial - genetics ; Europe ; Evolution ; Finger Phalanges - chemistry ; Fossils ; Gene Flow ; Genome - genetics ; Genomics ; Genètica ; Hominidae - classification ; Hominidae - genetics ; Hominids ; Homínids ; Humans ; Melanesia ; Molecular Sequence Data ; Morphology ; Paleontology ; Phylogeny ; Siberia ; Tooth - anatomy & histology ; Tooth - chemistry
É parte de: Nature (London), 2010-12, Vol.468 (7327), p.1053-1060
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Author Information The raw sequence data from the two Denisova fossils, the seven present-day humans, and the tooth mtDNA have been deposited in the European Nucleotide Archive at EMBL-EBI under accession numbers ERP000318, ERP000121 and FR695060, respectively. The alignments of Denisova sequence reads to the human and chimpanzee genomes are accessible for browsing and download from http://genome.ucsc.edu/Denisova.
These authors contributed equally to this work.
Author Contributions J.Kr., T.M., Q.F. and M.M. performed the experiments; D.R., R.E.G., M.K., J.Kr., N.P., E.Y.D., A.W.B., U.S., P.L.F.J., T.M., J.M.G., T.B.-M., C.A., S.M., H.L., E.E.E., M.St., J.Ke., M.Sl. and S.P. analysed genetic data; B.V., M.R., S.T., M.V.S., A.P.D. and J.-J.H. analysed archaeological and anthropological data; D.R. and S.P. wrote and edited the manuscript.
Descrição: Using DNA extracted from a finger bone found in Denisova Cave in southern Siberia, we have sequenced the genome of an archaic hominin to about 1.9-fold coverage. This individual is from a group that shares a common origin with Neanderthals. This population was not involved in the putative gene flow from Neanderthals into Eurasians; however, the data suggest that it contributed 4-6% of its genetic material to the genomes of present-day Melanesians. We designate this hominin population 'Denisovans' and suggest that it may have been widespread in Asia during the Late Pleistocene epoch. A tooth found in Denisova Cave carries a mitochondrial genome highly similar to that of the finger bone. This tooth shares no derived morphological features with Neanderthals or modern humans, further indicating that Denisovans have an evolutionary history distinct from Neanderthals and modern humans.
Editor: England: Nature Publishing Group
Idioma: Inglês

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Genetic history of an archaic hominin group from Denisova Cave in Siberia

England: Nature Publishing Group

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