Idioma:

Antibodies to the 70 kDa heat shock protein in midtrimester amniotic fluid and intraamniotic immunity

Gelber, Shari E., MD, PhD ; Bongiovanni, Ann Marie, BA ; Jean-Pierre, Claudel, MD ; Linhares, Iara M., MD ; Skupski, Daniel W., MD ; Witkin, Steven S., PhD

American journal of obstetrics and gynecology, 2007-09, Vol.197 (3), p.278.e1-278.e4 [Periódico revisado por pares]

Philadelphia, PA: Elsevier Inc

Texto completo disponível

Citações Citado por

Enviar para

Título:
Antibodies to the 70 kDa heat shock protein in midtrimester amniotic fluid and intraamniotic immunity
Autor: Gelber, Shari E., MD, PhD ; Bongiovanni, Ann Marie, BA ; Jean-Pierre, Claudel, MD ; Linhares, Iara M., MD ; Skupski, Daniel W., MD ; Witkin, Steven S., PhD
Assuntos: Adolescent ; Adult ; Amniocentesis ; amniotic fluid ; Amniotic Fluid - chemistry ; Amniotic Fluid - immunology ; Biological and medical sciences ; Female ; Gynecology. Andrology. Obstetrics ; heat shock protein ; heat shock protein antibodies ; HSP70 Heat-Shock Proteins - immunology ; Humans ; immune regulation ; Immunoglobulin G - biosynthesis ; Immunoglobulin G - immunology ; interferon-α ; Medical sciences ; Middle Aged ; Obstetrics and Gynecology ; Pregnancy - immunology ; Pregnancy Outcome ; Pregnancy Trimester, Second - immunology ; secretory leukocyte protease inhibitor ; tumor necrosis factor-α
É parte de: American journal of obstetrics and gynecology, 2007-09, Vol.197 (3), p.278.e1-278.e4
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Objective Antibodies to the 70 kDa heat shock protein (hsp70) immunoglobulin (Ig) G are markers for exposure to adverse or nonphysiological stimuli. In addition, these antibodies cross-link hsp-70 microbial antigen complexes and enhance development of antimicrobial immunity. The association between intraamniotic hsp70 IgG concentrations and intraamniotic immune responses were evaluated. Study Design Midtrimester amniotic fluids from 90 women undergoing an amniocentesis were tested for hsp70 IgG, hsp70 antigen, tumor necrosis factor (TNF)-α, secretory leukocyte protease inhibitor (SLPI), and interferon (IFN)-α by enzyme-linked immunosorbent assay. Clinical outcomes were obtained after completion of all testing. Associations were analyzed by nonparametric statistics. Results Intraamniotic hsp70 IgG concentrations, but not hsp70 antigen levels, were positively associated with levels of TNF-α ( P < .0001), IFN-α ( P = .0001), and SLPI ( P = .0038). There were no associations between hsp70 IgG and maternal age or parity, race/ethnicity or pregnancy outcome. Conclusion The hsp70 IgG levels correlate with intraamniotic concentrations of antimicrobial immune mediators. This antibody may potentiate antimicrobial immunity during fetal development.
Editor: Philadelphia, PA: Elsevier Inc
Idioma: Inglês

Links

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

Antibodies to the 70 kDa heat shock protein in midtrimester amniotic fluid and intraamniotic immunity

Gelber, Shari E., MD, PhD ; Bongiovanni, Ann Marie, BA ; Jean-Pierre, Claudel, MD ; Linhares, Iara M., MD ; Skupski, Daniel W., MD ; Witkin, Steven S., PhD

Philadelphia, PA: Elsevier Inc

Buscando em bases de dados remotas. Favor aguardar.