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Design and Characterization of Myristoylated and Non-Myristoylated Peptides Effective against Candida spp. Clinical Isolates

Bugli, Francesca ; Massaro, Federica ; Buonocore, Francesco ; Saraceni, Paolo Roberto ; Borocci, Stefano ; Ceccacci, Francesca ; Bombelli, Cecilia ; Di Vito, Maura ; Marchitiello, Rosalba ; Mariotti, Melinda ; Torelli, Riccardo ; Sanguinetti, Maurizio ; Porcelli, Fernando

International journal of molecular sciences, 2022-02, Vol.23 (4), p.2164 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Design and Characterization of Myristoylated and Non-Myristoylated Peptides Effective against Candida spp. Clinical Isolates
Autor: Bugli, Francesca ; Massaro, Federica ; Buonocore, Francesco ; Saraceni, Paolo Roberto ; Borocci, Stefano ; Ceccacci, Francesca ; Bombelli, Cecilia ; Di Vito, Maura ; Marchitiello, Rosalba ; Mariotti, Melinda ; Torelli, Riccardo ; Sanguinetti, Maurizio ; Porcelli, Fernando
Assuntos: Animals ; Antibiotics ; Antifungal activity ; Antifungal agents ; Antifungal Agents - chemistry ; Antifungal Agents - pharmacology ; Antiinfectives and antibacterials ; Antimicrobial agents ; Antimicrobial peptides ; Bacteria ; Biofilms ; Candida ; Candida albicans ; Clinical isolates ; Cytotoxicity ; Design ; Fatty acids ; Fungal infections ; Fungi ; Fungicides ; Gram-positive bacteria ; Humans ; in vivo infection control ; In vivo methods and tests ; Larva ; Larvae ; Lipids ; lipopeptide ; Lipopeptides ; Lipopeptides - pharmacology ; Mammalian cells ; Mammals ; Membrane vesicles ; Membranes ; Microbial Sensitivity Tests ; Mimicry ; Multidrug resistance ; Multidrug resistant organisms ; myristoylation ; N-Terminus ; Pathogens ; Peptides ; Public health ; Spectrum analysis
É parte de: International journal of molecular sciences, 2022-02, Vol.23 (4), p.2164
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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These authors contributed equally to this work.
Descrição: The increasing resistance of fungi to antibiotics is a severe challenge in public health, and newly effective drugs are required. Promising potential medications are lipopeptides, linear antimicrobial peptides (AMPs) conjugated to a lipid tail, usually at the N-terminus. In this paper, we investigated the in vitro and in vivo antifungal activity of three short myristoylated and non-myristoylated peptides derived from a mutant of the AMP . We determined their interaction with anionic and zwitterionic membrane-mimicking vesicles and their structure during this interaction. We then investigated their cytotoxic and hemolytic activity against mammalian cells. Lipidated peptides showed a broad spectrum of activity against a relevant panel of pathogen fungi belonging to spp., including the multidrug-resistant . The antifungal activity was also observed vs. biofilms of , , and . Finally, a pilot efficacy study was conducted on the in vivo model consisting of larvae. Treatment with the most-promising myristoylated peptide was effective in counteracting the infection from and and the death of the larvae. Therefore, this myristoylated peptide is a potential candidate to develop antifungal agents against human fungal pathogens.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Design and Characterization of Myristoylated and Non-Myristoylated Peptides Effective against Candida spp. Clinical Isolates

Bugli, Francesca ; Massaro, Federica ; Buonocore, Francesco ; Saraceni, Paolo Roberto ; Borocci, Stefano ; Ceccacci, Francesca ; Bombelli, Cecilia ; Di Vito, Maura ; Marchitiello, Rosalba ; Mariotti, Melinda ; Torelli, Riccardo ; Sanguinetti, Maurizio ; Porcelli, Fernando

Switzerland: MDPI AG

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