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Common and distinct clinical features in adult patients with anti-aminoacyl-tRNA synthetase antibodies: heterogeneity within the syndrome

Hamaguchi, Yasuhito ; Fujimoto, Manabu ; Matsushita, Takashi ; Kaji, Kenzo ; Komura, Kazuhiro ; Hasegawa, Minoru ; Kodera, Masanari ; Muroi, Eiji ; Fujikawa, Keita ; Seishima, Mariko ; Yamada, Hidehiro ; Yamada, Ryo ; Sato, Shinichi ; Takehara, Kazuhiko ; Kuwana, Masataka Miller, Frederick

PloS one, 2013-04, Vol.8 (4), p.e60442-e60442 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Common and distinct clinical features in adult patients with anti-aminoacyl-tRNA synthetase antibodies: heterogeneity within the syndrome
Autor: Hamaguchi, Yasuhito ; Fujimoto, Manabu ; Matsushita, Takashi ; Kaji, Kenzo ; Komura, Kazuhiro ; Hasegawa, Minoru ; Kodera, Masanari ; Muroi, Eiji ; Fujikawa, Keita ; Seishima, Mariko ; Yamada, Hidehiro ; Yamada, Ryo ; Sato, Shinichi ; Takehara, Kazuhiko ; Kuwana, Masataka
Miller, Frederick
Assuntos: Adolescent ; Adrenal Cortex Hormones - therapeutic use ; Adult ; Aged ; Amino Acyl-tRNA Synthetases - immunology ; Aminoacyl-tRNA ligase ; Analysis ; Antibodies ; Arthritis ; Autoantibodies - blood ; Biology ; Dermatology ; Dermatomyositis ; Dermatomyositis - blood ; Dermatomyositis - drug therapy ; Dermatomyositis - epidemiology ; Dermatomyositis - immunology ; Exanthema ; Female ; Health care facilities ; Hospitals ; Humans ; Immunoglobulins ; Immunoprecipitation ; Inflammatory diseases ; Internal medicine ; Lung diseases ; Lung diseases, Interstitial ; Lung Diseases, Interstitial - blood ; Lung Diseases, Interstitial - epidemiology ; Lung Diseases, Interstitial - immunology ; Lupus Erythematosus, Systemic - blood ; Lupus Erythematosus, Systemic - epidemiology ; Lupus Erythematosus, Systemic - immunology ; Male ; Medical diagnosis ; Medicine ; Middle Aged ; Musculoskeletal diseases ; Myositis ; Pathogenesis ; Patients ; Polymyositis ; Polymyositis - blood ; Polymyositis - drug therapy ; Polymyositis - epidemiology ; Polymyositis - immunology ; Prevalence ; Rheumatology ; Science ; Scleroderma, Systemic - blood ; Scleroderma, Systemic - epidemiology ; Scleroderma, Systemic - immunology ; Skin ; Syndrome ; Transfer RNA ; tRNA ; University graduates ; Viral antibodies ; Young Adult
É parte de: PloS one, 2013-04, Vol.8 (4), p.e60442-e60442
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Competing Interests: The authors have declared that no competing interests exist.
Conceived and designed the experiments: YH MF. Performed the experiments: YH MF. Analyzed the data: YH RY MF. Contributed reagents/materials/analysis tools: YH MF TM K. Kaji K. Komura MH M. Kodera EM KF MS HY SS KT M. Kuwana. Wrote the paper: YH MF M. Kuwana.
Descrição: To identify similarities and differences in the clinical features of adult Japanese patients with individual anti-aminoacyl-tRNA synthetase antibodies (anti-ARS Abs). This was a retrospective analysis of 166 adult Japanese patients with anti-ARS Abs detected by immunoprecipitation assays. These patients had visited Kanazawa University Hospital or collaborating medical centers from 2003 to 2009. Anti-ARS Ab specificity included anti-Jo-1 (36%), anti-EJ (23%), anti-PL-7 (18%), anti-PL-12 (11%), anti-KS (8%), and anti-OJ (5%). These anti-ARS Abs were mutually exclusive, except for one serum Ab that had both anti-PL-7 and PL-12 reactivity. Myositis was closely associated with anti-Jo-1, anti-EJ, and anti-PL-7, while interstitial lung disease (ILD) was correlated with all 6 anti-ARS Abs. Dermatomyositis (DM)-specific skin manifestations (heliotrope rash and Gottron's sign) were frequently observed in patients with anti-Jo-1, anti-EJ, anti-PL-7, and anti-PL-12. Therefore, most clinical diagnoses were polymyositis or DM for anti-Jo-1, anti-EJ, and anti-PL-7; clinically amyopathic DM or ILD for anti-PL-12; and ILD for anti-KS and anti-OJ. Patients with anti-Jo-1, anti-EJ, and anti-PL-7 developed myositis later if they had ILD alone at the time of disease onset, and most patients with anti-ARS Abs eventually developed ILD if they did not have ILD at disease onset. Patients with anti-ARS Abs are relatively homogeneous. However, the distribution and timing of myositis, ILD, and rashes differ among patients with individual anti-ARS Abs. Thus, identification of individual anti-ARS Abs is beneficial to define this rather homogeneous subset and to predict clinical outcomes within the "anti-synthetase syndrome."
Editor: United States: Public Library of Science
Idioma: Inglês

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Common and distinct clinical features in adult patients with anti-aminoacyl-tRNA synthetase antibodies: heterogeneity within the syndrome

Hamaguchi, Yasuhito ; Fujimoto, Manabu ; Matsushita, Takashi ; Kaji, Kenzo ; Komura, Kazuhiro ; Hasegawa, Minoru ; Kodera, Masanari ; Muroi, Eiji ; Fujikawa, Keita ; Seishima, Mariko ; Yamada, Hidehiro ; Yamada, Ryo ; Sato, Shinichi ; Takehara, Kazuhiko ; Kuwana, Masataka Miller, Frederick

United States: Public Library of Science

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