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The Role of Transforming Growth Factor Beta and Smad Receptors in Determining Prognosis in High-Grade Primary Brain Tumors: Glioblastoma Multiforme

Gürsoy, Güven ; Barutçuoğlu, Mustafa ; Sivrikoz, Oya Nermin ; Gökalp, Sevtap ; Vatansever, Seda

Arquivos brasileiros de neurocirurgia, 2023-06, Vol.42 (2), p.e134-e144 [Periódico revisado por pares]

Thieme Revinter Publicações Ltda

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  • Título:
    The Role of Transforming Growth Factor Beta and Smad Receptors in Determining Prognosis in High-Grade Primary Brain Tumors: Glioblastoma Multiforme
  • Autor: Gürsoy, Güven ; Barutçuoğlu, Mustafa ; Sivrikoz, Oya Nermin ; Gökalp, Sevtap ; Vatansever, Seda
  • Assuntos: endothelial-mesenchymal transition ; glioblastoma multiforme ; smad proteins ; transforming growth factor beta
  • É parte de: Arquivos brasileiros de neurocirurgia, 2023-06, Vol.42 (2), p.e134-e144
  • Descrição: Abstract Introduction High-grade primary brain tumors cause serious morbidity and mortality. This study aimed to investigate the role of transforming growth factor beta (TGF-β) and suppressor of mothers against decapentaplegic (Smad) receptors in high-grade primary brain tumors. Material and Method Thirteen patients with a pathological diagnosis of glioblastoma multiforme were included in the study. Pathological preparations of each patient were analyzed retrospectively in histochemistry and immunohistochemistry laboratories. Transforming growth factor beta 1, TGF-β2, TGF-β3, Smad 1/2/3, Smad 6, and Smad 7 stainings were evaluated, and the immunoreactivity densities were examined. Result We found out an increase in the expression of TGF-β1 and TGF-β3 protein. Regarding the inhibitin receptors, Smad 6 showed much more expression than Smad 7. Thus, we found that Smad 6 has a protective effect and role in the tissue. Immunhistochemically, TGF-β family stains, which are activated by types I-and -II receptors, and the stainless staining of the Smad family might also be showing that the TGF-β family is taking action with a secondary pathway other than the Smad family. Conclusion In addition to Smad family receptors, Shc-GBR2, SARA, and Ras-Erk1/2 receptors should be investigated in future research. After that, the prognosis, diagnosis, and patient-based chemotherapy strategies for the treatment of glioblastoma multiforme may take a more prominent role.
  • Editor: Thieme Revinter Publicações Ltda
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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