Idioma:

Mitochondrial function in spinal cord injury and regeneration

Slater, Paula G. ; Domínguez-Romero, Miguel E. ; Villarreal, Maximiliano ; Eisner, Verónica ; Larraín, Juan

Cellular and molecular life sciences : CMLS, 2022-05, Vol.79 (5), p.239-239, Article 239 [Periódico revisado por pares]

Cham: Springer International Publishing

Texto completo disponível

Citações Citado por

Enviar para

Título:
Mitochondrial function in spinal cord injury and regeneration
Autor: Slater, Paula G. ; Domínguez-Romero, Miguel E. ; Villarreal, Maximiliano ; Eisner, Verónica ; Larraín, Juan
Assuntos: Animals ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Cell death ; Cell differentiation ; Cell self-renewal ; Cells (biology) ; Central nervous system ; Central Nervous System - metabolism ; Humans ; Immune response ; Injuries ; Life expectancy ; Life Sciences ; Life span ; Localization ; Mammals ; Metabolism ; Mitochondria ; Mitochondria - metabolism ; Nerve Regeneration ; Neural stem cells ; Paralysis ; Progenitor cells ; Recovery of Function ; Regeneration ; Review ; Spinal Cord - metabolism ; Spinal cord injuries ; Spinal Cord Injuries - metabolism ; Spinal Cord Regeneration - physiology ; Substrates ; Target recognition
É parte de: Cellular and molecular life sciences : CMLS, 2022-05, Vol.79 (5), p.239-239, Article 239
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Many people around the world suffer from some form of paralysis caused by spinal cord injury (SCI), which has an impact on quality and life expectancy. The spinal cord is part of the central nervous system (CNS), which in mammals is unable to regenerate, and to date, there is a lack of full functional recovery therapies for SCI. These injuries start with a rapid and mechanical insult, followed by a secondary phase leading progressively to greater damage. This secondary phase can be potentially modifiable through targeted therapies. The growing literature, derived from mammalian and regenerative model studies, supports a leading role for mitochondria in every cellular response after SCI: mitochondrial dysfunction is the common event of different triggers leading to cell death, cellular metabolism regulates the immune response, mitochondrial number and localization correlate with axon regenerative capacity, while mitochondrial abundance and substrate utilization regulate neural stem progenitor cells self-renewal and differentiation. Herein, we present a comprehensive review of the cellular responses during the secondary phase of SCI, the mitochondrial contribution to each of them, as well as evidence of mitochondrial involvement in spinal cord regeneration, suggesting that a more in-depth study of mitochondrial function and regulation is needed to identify potential targets for SCI therapeutic intervention.
Editor: Cham: Springer International Publishing
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Anterior Resultado 2 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Mitochondrial function in spinal cord injury and regeneration

Slater, Paula G. ; Domínguez-Romero, Miguel E. ; Villarreal, Maximiliano ; Eisner, Verónica ; Larraín, Juan

Cham: Springer International Publishing

Buscando em bases de dados remotas. Favor aguardar.