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Quantitative determination of ciprofloxacin and norfloxacin in pharmaceutical preparations by high performance liquid chromatography

Kassab, Nájla Mohamad ; Singh, Anil Kumar ; Kedor-Hackmam, Erika Rosa Maria ; Santoro, Maria Inês Rocha Miritello

Revista brasileira de ciências farmacêuticas, 2005-12, Vol.41 (4), p.507-513

Divisão de Biblioteca e Documentação do Conjunto das Químicas da Universidade de São Paulo

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  • Título:
    Quantitative determination of ciprofloxacin and norfloxacin in pharmaceutical preparations by high performance liquid chromatography
  • Autor: Kassab, Nájla Mohamad ; Singh, Anil Kumar ; Kedor-Hackmam, Erika Rosa Maria ; Santoro, Maria Inês Rocha Miritello
  • Assuntos: PHARMACOLOGY & PHARMACY
  • É parte de: Revista brasileira de ciências farmacêuticas, 2005-12, Vol.41 (4), p.507-513
  • Descrição: The objective of this research was to develop and validate an analytical method for quantitative determination of ciprofloxacin (CIP) and norfloxacin (NOR) in pharmaceutical preparations. A simple and rapid chromatographic method was developed and validated for quantitative determination of two fluoroquinolone antibiotics in tablets and injection preparations. The quinolones were analyzed by using a LiChrospher® 100 RP-18 column (5 µm, 125 x 4 mm) and a mobile phase consisted of water:acetonitrile:triethylamine (80:20:0.3 v/v/v). The pH of final mixture was adjusted to 3.3 with phosphoric acid. The flow rate was 1.0 mL/min and UV detection was made at 279 nm. The analyses were performed at room temperature (24 ± 2 ºC). CIP and NOR were eluted within 5 min. The calibration curves were linear (r > 0.9999) over a concentration range from 4.0 to 24.0 µg/mL. The relative standard deviation (RSD) was < 1.0% and the mean recovery was 101.85%.
  • Editor: Divisão de Biblioteca e Documentação do Conjunto das Químicas da Universidade de São Paulo
  • Idioma: Inglês;Português
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