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A genome-wide association study of anorexia nervosa

Floyd, J A B ; Southam, L ; Rayner, N W ; Treasure, J ; Schmidt, U ; Tozzi, F ; Gorwood, P ; Adan, R A H ; Favaro, A ; Santonastaso, P ; Gratacos, M ; Keski-Rahkonen, A ; Van Furth, E F ; Slof-Op 't Landt, M C T ; Reichborn-Kjennerud, T ; Knudsen, G P S ; Monteleone, P ; Kaplan, A S ; Karwautz, A ; Li, D ; Schork, N J ; Komaki, G ; Inoko, H ; Esko, T ; Baker, J H ; Hilliard, C E ; O'Toole, J K ; Pantel, J ; Szatkiewicz, J P ; Taico, C ; Burghardt, R ; de Zwaan, M ; Egberts, K ; Imgart, H ; Scherag, A ; Zipfel, S ; Versini, A ; Brandys, M K ; de Kovel, C ; Hendriks, J ; Koeleman, B P C ; Ophoff, R A ; Strengman, E ; Bruson, A ; Escaramís, G ; Jiménez-Murcia, S ; Rajewski, A ; Szeszenia-Dabrowska, N ; Slopien, A ; Hauser, J ; Slagboom, P E ; Maj, M ; Dedoussis, G ; Dikeos, D ; Tziouvas, K ; Papezova, H ; Slachtova, L ; Martaskova, D ; Kennedy, J L ; Levitan, R D ; Koubek, D ; Merl, E ; Wagner, G ; Lichtenstein, P ; Breen, G ; Farmer, A ; McGuffin, P ; Giegling, I ; Herms, S ; Wichmann, H-E ; Dina, C ; Sladek, R ; Gambaro, G ; Julia, A ; Gaborieau, V ; Dick, D M ; Ripatti, S ; Widén, E ; Espeseth, T ; Lundervold, A ; Reinvang, I ; Steen, V M ; Ntalla, I ; Foretova, L ; Navratilova, M ; Pinto, D ; Scherer, S W ; Aschauer, H ; Schosser, A ; Courtet, P ; Guillaume, S ; Jaussent, I ; Finan, C ; Kalsi, G ; Roberts, M ; Logan, D W ; Peltonen, L ; Ritchie, G R S ; Barrett, J C ; Sullivan, P F

Molecular psychiatry, 2014-10, Vol.19 (10), p.1085-1094 [Periódico revisado por pares]

England: Nature Publishing Group

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Título:
A genome-wide association study of anorexia nervosa
Autor: Floyd, J A B ; Southam, L ; Rayner, N W ; Treasure, J ; Schmidt, U ; Tozzi, F ; Gorwood, P ; Adan, R A H ; Favaro, A ; Santonastaso, P ; Gratacos, M ; Keski-Rahkonen, A ; Van Furth, E F ; Slof-Op 't Landt, M C T ; Reichborn-Kjennerud, T ; Knudsen, G P S ; Monteleone, P ; Kaplan, A S ; Karwautz, A ; Li, D ; Schork, N J ; Komaki, G ; Inoko, H ; Esko, T ; Baker, J H ; Hilliard, C E ; O'Toole, J K ; Pantel, J ; Szatkiewicz, J P ; Taico, C ; Burghardt, R ; de Zwaan, M ; Egberts, K ; Imgart, H ; Scherag, A ; Zipfel, S ; Versini, A ; Brandys, M K ; de Kovel, C ; Hendriks, J ; Koeleman, B P C ; Ophoff, R A ; Strengman, E ; Bruson, A ; Escaramís, G ; Jiménez-Murcia, S ; Rajewski, A ; Szeszenia-Dabrowska, N ; Slopien, A ; Hauser, J ; Slagboom, P E ; Maj, M ; Dedoussis, G ; Dikeos, D ; Tziouvas, K ; Papezova, H ; Slachtova, L ; Martaskova, D ; Kennedy, J L ; Levitan, R D ; Koubek, D ; Merl, E ; Wagner, G ; Lichtenstein, P ; Breen, G ; Farmer, A ; McGuffin, P ; Giegling, I ; Herms, S ; Wichmann, H-E ; Dina, C ; Sladek, R ; Gambaro, G ; Julia, A ; Gaborieau, V ; Dick, D M ; Ripatti, S ; Widén, E ; Espeseth, T ; Lundervold, A ; Reinvang, I ; Steen, V M ; Ntalla, I ; Foretova, L ; Navratilova, M ; Pinto, D ; Scherer, S W ; Aschauer, H ; Schosser, A ; Courtet, P ; Guillaume, S ; Jaussent, I ; Finan, C ; Kalsi, G ; Roberts, M ; Logan, D W ; Peltonen, L ; Ritchie, G R S ; Barrett, J C ; Sullivan, P F
Assuntos: Anorexia ; Anorexia nervosa ; Anorexia Nervosa - genetics ; Asian Continental Ancestry Group/genetics ; Asian People - genetics ; Body weight ; Calcineurin - genetics ; Carrier Proteins - genetics ; Case-Control Studies ; Cullin Proteins - genetics ; Datasets ; Eating disorders ; Epidemiology ; European Continental Ancestry Group/genetics ; Female ; Genetic aspects ; Genetics & genetic processes ; Genome-wide association studies ; Genome-Wide Association Study ; Genomes ; Genotyping ; Guanine Nucleotide Exchange Factors - genetics ; Génétique & processus génétiques ; Humans ; Japan ; Life sciences ; Male ; Medicin och hälsovetenskap ; Meta-Analysis as Topic ; Nuclear Proteins - genetics ; Patient outcomes ; Polymorphism, Single Nucleotide ; Psychological aspects ; Replication ; Sciences du vivant ; Single-nucleotide polymorphism ; Systematic review ; White People - genetics
É parte de: Molecular psychiatry, 2014-10, Vol.19 (10), p.1085-1094
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
scopus-id:2-s2.0-84905856652
These authors contributed equally to this manuscript
These authors contributed equally to this manuscript as investigators
Descrição: Anorexia nervosa (AN) is a complex and heritable eating disorder characterized by dangerously low body weight. Neither candidate gene studies nor an initial genome-wide association study (GWAS) have yielded significant and replicated results. We performed a GWAS in 2907 cases with AN from 14 countries (15 sites) and 14 860 ancestrally matched controls as part of the Genetic Consortium for AN (GCAN) and the Wellcome Trust Case Control Consortium 3 (WTCCC3). Individual association analyses were conducted in each stratum and meta-analyzed across all 15 discovery data sets. Seventy-six (72 independent) single nucleotide polymorphisms were taken forward for in silico (two data sets) or de novo (13 data sets) replication genotyping in 2677 independent AN cases and 8629 European ancestry controls along with 458 AN cases and 421 controls from Japan. The final global meta-analysis across discovery and replication data sets comprised 5551 AN cases and 21 080 controls. AN subtype analyses (1606 AN restricting; 1445 AN binge-purge) were performed. No findings reached genome-wide significance. Two intronic variants were suggestively associated: rs9839776 (P=3.01 × 10(-7)) in SOX2OT and rs17030795 (P=5.84 × 10(-6)) in PPP3CA. Two additional signals were specific to Europeans: rs1523921 (P=5.76 × 10(-)(6)) between CUL3 and FAM124B and rs1886797 (P=8.05 × 10(-)(6)) near SPATA13. Comparing discovery with replication results, 76% of the effects were in the same direction, an observation highly unlikely to be due to chance (P=4 × 10(-6)), strongly suggesting that true findings exist but our sample, the largest yet reported, was underpowered for their detection. The accrual of large genotyped AN case-control samples should be an immediate priority for the field.
Editor: England: Nature Publishing Group
Idioma: Inglês

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A genome-wide association study of anorexia nervosa

England: Nature Publishing Group

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