Idioma:

Effect of apomorphine and gabaergic drugs in monkeys pretreated with haloperidol

Bjørndal, N ; Gerlach, J ; Casey, D E ; Christensson, E

Psychopharmacology, 1983-01, Vol.79 (2-3), p.220-225 [Periódico revisado por pares]

Germany

Texto completo disponível

Citações Citado por

Enviar para

Título:
Effect of apomorphine and gabaergic drugs in monkeys pretreated with haloperidol
Autor: Bjørndal, N ; Gerlach, J ; Casey, D E ; Christensson, E
Assuntos: 4-Aminobutyrate Transaminase - antagonists & inhibitors ; Alkynes ; Aminocaproates - pharmacology ; Animals ; Apomorphine - pharmacology ; Cercopithecus aethiops ; Female ; gamma-Aminobutyric Acid - physiology ; Haloperidol - pharmacology ; Hemodynamics - drug effects ; Isoxazoles - pharmacology ; Male ; Motor Activity - drug effects ; Muscimol - pharmacology ; Picrotoxin - pharmacology
É parte de: Psychopharmacology, 1983-01, Vol.79 (2-3), p.220-225
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
Descrição: The behavioural effects of apomorphine and GABAergic drugs alone and in combination were studied in eight monkeys (Cercopithecus aethiops ) showing behavioural supersensitivity to dopamine agonists after long-term haloperidol treatment. Apomorphine (0.1-0.5 mg/kg SC) produced an increase in locomotion, repetitive movements of head, limbs and trunk, oral hyperkinesia (licking and chewing) and reactivity. Gamma-acetylenic GABA (GAG, a GABA transaminase inhibitor, 50-100 mg/kg SC) reduced spontaneous activity in two monkeys, but otherwise had no behavioural effect when given alone. The findings suggest that apomorphine and GABA agonists induce distinct types of behaviour, possibly related to a differential influence on separate dopamine/GABA receptors, and that GABA agonists in relatively high doses counteract apomorphine-induced behaviour with the exception that THIP does not influence oral hyperkinesia.
Editor: Germany
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Anterior Resultado 7 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Effect of apomorphine and gabaergic drugs in monkeys pretreated with haloperidol

Bjørndal, N ; Gerlach, J ; Casey, D E ; Christensson, E

Germany

Buscando em bases de dados remotas. Favor aguardar.