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SUSCEPTIBILITY TEST FOR FUNGI: CLINICAL AND LABORATORIAL CORRELATIONS IN MEDICAL MYCOLOGY

Alastruey-Izquierdo, Ana ; Melhem, Marcia S C ; Bonfietti, Lucas X ; Rodriguez-Tudela, Juan L

Revista do Instituto de Medicina Tropical de São Paulo, 2015-09, Vol.57 Suppl 19 (suppl 19), p.57-64 [Periódico revisado por pares]

Brazil: Instituto de Medicina Tropical de Sao Paulo

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  • Título:
    SUSCEPTIBILITY TEST FOR FUNGI: CLINICAL AND LABORATORIAL CORRELATIONS IN MEDICAL MYCOLOGY
  • Autor: Alastruey-Izquierdo, Ana ; Melhem, Marcia S C ; Bonfietti, Lucas X ; Rodriguez-Tudela, Juan L
  • Assuntos: Antifungal Agents - pharmacology ; Aspergillus - classification ; Aspergillus - drug effects ; Candida - classification ; Candida - drug effects ; Drug Resistance, Fungal ; Fungi ; Humans ; Microbial Sensitivity Tests - methods ; Susceptibility test ; TROPICAL MEDICINE
  • É parte de: Revista do Instituto de Medicina Tropical de São Paulo, 2015-09, Vol.57 Suppl 19 (suppl 19), p.57-64
  • Notas: ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
  • Descrição: During recent decades, antifungal susceptibility testing has become standardized and nowadays has the same role of the antibacterial susceptibility testing in microbiology laboratories. American and European standards have been developed, as well as equivalent commercial systems which are more appropriate for clinical laboratories. The detection of resistant strains by means of these systems has allowed the study and understanding of the molecular basis and the mechanisms of resistance of fungal species to antifungal agents. In addition, many studies on the correlation of in vitro results with the outcome of patients have been performed, reaching the conclusion that infections caused by resistant strains have worse outcome than those caused by susceptible fungal isolates. These studies have allowed the development of interpretative breakpoints for Candida spp. and Aspergillus spp., the most frequent agents of fungal infections in the world. In summary, antifungal susceptibility tests have become essential tools to guide the treatment of fungal diseases, to know the local and global disease epidemiology, and to identify resistance to antifungals.
  • Editor: Brazil: Instituto de Medicina Tropical de Sao Paulo
  • Idioma: Inglês;Português
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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