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Evolution-proof inhibitors of public good cooperation: a screening strategy inspired by social evolution theory

Lissens, Maries ; Joos, Mathieu ; Lories, Bram ; Steenackers, Hans P

FEMS microbiology reviews, 2022-10, Vol.46 (5), p.1 [Periódico revisado por pares]

England: Oxford University Press

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  • Título:
    Evolution-proof inhibitors of public good cooperation: a screening strategy inspired by social evolution theory
  • Autor: Lissens, Maries ; Joos, Mathieu ; Lories, Bram ; Steenackers, Hans P
  • Assuntos: Analysis ; Bacterial infections ; Behavior evolution ; Biological Evolution ; Diggle, Steve ; Drug resistance in microorganisms ; Review ; Social Evolution ; Virulence (Microbiology)
  • É parte de: FEMS microbiology reviews, 2022-10, Vol.46 (5), p.1
  • Notas: ObjectType-Article-1
    SourceType-Scholarly Journals-1
    ObjectType-Feature-2
    content type line 23
  • Descrição: Interference with public good cooperation provides a promising novel antimicrobial strategy since social evolution theory predicts that resistant mutants will be counter-selected if they share the public benefits of their resistance with sensitive cells in the population. Although this hypothesis is supported by a limited number of pioneering studies, an extensive body of more fundamental work on social evolution describes a multitude of mechanisms and conditions that can stabilize public behaviour, thus potentially allowing resistant mutants to thrive. In this paper we theorize on how these different mechanisms can influence the evolution of resistance against public good inhibitors. Based hereon, we propose an innovative 5-step screening strategy to identify novel evolution-proof public good inhibitors, which involves a systematic evaluation of the exploitability of public goods under the most relevant experimental conditions, as well as a careful assessment of the most optimal way to interfere with their action. Overall, this opinion paper is aimed to contribute to long-term solutions to fight bacterial infections.
  • Editor: England: Oxford University Press
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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