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Multigrowth Factor Delivery via Immobilization of Gene Therapy Vectors

Hao, Jie ; Cheng, Kenneth C. K. ; Kruger, Laura G. ; Larsson, Lena ; Sugai, James V. ; Lahann, Joerg ; Giannobile, William V.

Advanced materials (Weinheim), 2016-04, Vol.28 (16), p.3145-3151 [Periódico revisado por pares]

Germany: Blackwell Publishing Ltd

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Título:
Multigrowth Factor Delivery via Immobilization of Gene Therapy Vectors
Autor: Hao, Jie ; Cheng, Kenneth C. K. ; Kruger, Laura G. ; Larsson, Lena ; Sugai, James V. ; Lahann, Joerg ; Giannobile, William V.
Assuntos: Adenoviridae - genetics ; Adenoviridae - immunology ; Antibodies, Immobilized - chemistry ; Biocompatible Materials - chemistry ; Biomaterials ; Biomedical materials ; bone morphogenetic protein-7 ; bone morphogenetic proteins ; Cells, Cultured ; Chemical vapor deposition ; Chemistry ; Clinical Medicine ; defects ; differentiation ; drug delivery ; Gene therapy ; gene transfer ; Gene Transfer Techniques ; Genetic Therapy - methods ; Genetic Vectors - genetics ; Genetic Vectors - immunology ; Humans ; in-vitro ; Intercellular Signaling Peptides and Proteins - biosynthesis ; Intercellular Signaling Peptides and Proteins - genetics ; Klinisk medicin ; ligament ; Materials Science ; Materials selection ; Mathematical analysis ; microparticles ; osseointegration ; Periodontal Ligament - cytology ; Physics ; platelet-derived growth factor ; regeneration ; regenerative medicine ; Regenerative Medicine - methods ; scaffolds ; Science & Technology - Other Topics ; Surgical implants ; tissue regeneration ; Vectors (mathematics) ; vivo ; Wound Healing
É parte de: Advanced materials (Weinheim), 2016-04, Vol.28 (16), p.3145-3151
Notas: NIH - No. DE13397
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Descrição: Molecules can be immobilized onto biomaterials by a chemical vapor deposition (CVD) coating strategy. Pentafluorophenolester groups react with amine side chains on antibodies, which can selectively immobilize adenoviral vectors for gene delivery of growth factors. These vectors can produce functional proteins within defined regions of biomaterials to produce customizable structures for targeted tissue regeneration.
Editor: Germany: Blackwell Publishing Ltd
Idioma: Inglês

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Multigrowth Factor Delivery via Immobilization of Gene Therapy Vectors

Hao, Jie ; Cheng, Kenneth C. K. ; Kruger, Laura G. ; Larsson, Lena ; Sugai, James V. ; Lahann, Joerg ; Giannobile, William V.

Germany: Blackwell Publishing Ltd

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