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Cell intrinsic control of axon regeneration

Mar, Fernando M ; Bonni, Azad ; Sousa, Mónica M

EMBO reports, 2014-03, Vol.15 (3), p.254-263 [Periódico revisado por pares]

England: Blackwell Publishing Ltd

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  • Título:
    Cell intrinsic control of axon regeneration
  • Autor: Mar, Fernando M ; Bonni, Azad ; Sousa, Mónica M
  • Assuntos: Animals ; axon regeneration ; Axonal Transport ; Axons - metabolism ; Axons - physiology ; Cellular biology ; conditioning lesion ; Cytoskeleton ; Humans ; microtubule dynamics ; Microtubule Proteins - genetics ; Microtubule Proteins - metabolism ; Nerve Regeneration ; Neurological disorders ; Neurons ; Reviews
  • É parte de: EMBO reports, 2014-03, Vol.15 (3), p.254-263
  • Notas: FCT - No. FCOMP-01-0124-FEDER-017455; No. HMSP-ICT/0020/2010; No. FCOMP-01-0124-FEDER-015781; No. PTDC/SAU-GMG/111761/2009
    istex:69926F98A9512E785F01BE52992B32EE6014E367
    FEDER
    International Foundation for Research in Paraplegia
    NIH - No. NS051255
    ark:/67375/WNG-CTQRBZZP-0
    ArticleID:EMBR201337723
    ObjectType-Article-2
    SourceType-Scholarly Journals-1
    ObjectType-Feature-3
    content type line 23
    ObjectType-Review-1
    See the Glossary for abbreviations used in this article.
  • Descrição: Although neurons execute a cell intrinsic program of axonal growth during development, following the establishment of connections, the developmental growth capacity declines. Besides environmental challenges, this switch largely accounts for the failure of adult central nervous system (CNS) axons to regenerate. Here, we discuss the cell intrinsic control of axon regeneration, including not only the regulation of transcriptional and epigenetic mechanisms, but also the modulation of local protein translation, retrograde and anterograde axonal transport, and microtubule dynamics. We further explore the causes underlying the failure of CNS neurons to mount a vigorous regenerative response, and the paradigms demonstrating the activation of cell intrinsic axon growth programs. Finally, we present potential mechanisms to support axon regeneration, as these may represent future therapeutic approaches to promote recovery following CNS injury and disease. This review discusses the cell intrinsic responses to axon injury that—if activated—might enhance the limited regenerative capacity of CNS neurons, and the relevance of new findings to possible therapeutic approaches.
  • Editor: England: Blackwell Publishing Ltd
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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