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Addressing Therapeutic Options for Ebola Virus Infection in Current and Future Outbreaks

Haque, Azizul ; Hober, Didier ; Blondiaux, Joel

Antimicrobial agents and chemotherapy, 2015-10, Vol.59 (10), p.5892-5902 [Periódico revisado por pares]

United States: American Society for Microbiology

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Título:
Addressing Therapeutic Options for Ebola Virus Infection in Current and Future Outbreaks
Autor: Haque, Azizul ; Hober, Didier ; Blondiaux, Joel
Assuntos: Amides - pharmacology ; Amidines - pharmacology ; Androstenes - pharmacology ; Animals ; Anti-Inflammatory Agents ; Anti-Inflammatory Agents - pharmacology ; Antibodies, Monoclonal - pharmacology ; Antiviral Agents ; Antiviral Agents - pharmacology ; Benzofurans - pharmacology ; Biological anthropology ; Cellular Biology ; Cytosine - analogs & derivatives ; Cytosine - pharmacology ; Disease Models, Animal ; Disease Outbreaks ; Disease Outbreaks - prevention & control ; Ebolavirus ; Ebolavirus - drug effects ; Ebolavirus - genetics ; Ebolavirus - growth & development ; Ebolavirus - metabolism ; Hemorrhagic Fever, Ebola ; Hemorrhagic Fever, Ebola - drug therapy ; Hemorrhagic Fever, Ebola - mortality ; Hemorrhagic Fever, Ebola - pathology ; Hemorrhagic Fever, Ebola - virology ; Human health and pathology ; Humanities and Social Sciences ; Humans ; Immune Sera - pharmacology ; Immunology ; Life Sciences ; Minireview ; Minireviews ; Organophosphonates - pharmacology ; Pyrazines - pharmacology ; RNA, Small Interfering - genetics ; RNA, Small Interfering - metabolism ; Social Anthropology and ethnology ; Sociology ; Stilbenes - pharmacology ; Virus Replication - drug effects
É parte de: Antimicrobial agents and chemotherapy, 2015-10, Vol.59 (10), p.5892-5902
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
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PMCID: PMC4576072
Citation Haque A, Hober D, Blondiaux J. 2015. Addressing therapeutic options for Ebola virus infection in current and future outbreaks. Antimicrob Agents Chemother 59:5892–5902. doi:10.1128/AAC.01105-15.
Descrição: Ebola virus can cause severe hemorrhagic disease with high fatality rates. Currently, no specific therapeutic agent or vaccine has been approved for treatment and prevention of Ebola virus infection of humans. Although the number of Ebola cases has fallen in the last few weeks, multiple outbreaks of Ebola virus infection and the likelihood of future exposure highlight the need for development and rapid evaluation of pre- and postexposure treatments. Here, we briefly review the existing and future options for anti-Ebola therapy, based on the data coming from rare clinical reports, studies on animals, and results from in vitro models. We also project the mechanistic hypotheses of several potential drugs against Ebola virus, including small-molecule-based drugs, which are under development and being tested in animal models or in vitro using various cell types. Our paper discusses strategies toward identifying and testing anti-Ebola virus properties of known and medically approved drugs, especially those that can limit the pathological inflammatory response in Ebola patients and thereby provide protection from mortality. We underline the importance of developing combinational therapy for better treatment outcomes for Ebola patients.
Editor: United States: American Society for Microbiology
Idioma: Inglês

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Addressing Therapeutic Options for Ebola Virus Infection in Current and Future Outbreaks

Haque, Azizul ; Hober, Didier ; Blondiaux, Joel

United States: American Society for Microbiology

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