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Microneedle-based interstitial fluid extraction for drug analysis: Advances, challenges, and prospects

Ma, Shuwen ; Li, Jiaqi ; Pei, Lixia ; Feng, Nianping ; Zhang, Yongtai

Journal of pharmaceutical analysis, 2023-02, Vol.13 (2), p.111-126 [Periódico revisado por pares]

China: Elsevier B.V

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Título:
Microneedle-based interstitial fluid extraction for drug analysis: Advances, challenges, and prospects
Autor: Ma, Shuwen ; Li, Jiaqi ; Pei, Lixia ; Feng, Nianping ; Zhang, Yongtai
Assuntos: Acupuncture ; Anticoagulants ; Biomarker ; Biomarkers ; Blood substitutes ; Body fluids ; Coronaviruses ; Diagnosis ; Drug delivery ; Drug dosages ; Drug testing ; Hydrogels ; Interstitial fluid ; Microneedle ; Patients ; Pharmaceutical analysis ; Pharmacokinetics ; Review Paper ; Sensors ; Severe acute respiratory syndrome ; Severe acute respiratory syndrome coronavirus 2 ; Skin ; Transdermal medication
É parte de: Journal of pharmaceutical analysis, 2023-02, Vol.13 (2), p.111-126
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Both authors contributed equally to this work.
Descrição: Similar to blood, interstitial fluid (ISF) contains exogenous drugs and biomarkers and may therefore substitute blood in drug analysis. However, current ISF extraction techniques require bulky instruments and are both time-consuming and complicated, which has inspired the development of viable alternatives such as those relying on skin or tissue puncturing with microneedles. Currently, microneedles are widely employed for transdermal drug delivery and have been successfully used for ISF extraction by different mechanisms to facilitate subsequent analysis. The integration of microneedles with sensors enables in situ ISF analysis and specific compound monitoring, while the integration of monitoring and delivery functions in wearable devices allows real-time dose modification. Herein, we review the progress in drug analysis based on microneedle-assisted ISF extraction and discuss the related future opportunities and challenges. [Display omitted] •The advances in microneedle-assisted interstitial fluid extraction for drug analysis are reviewed.•The microneedles-mediated wearable devices for diagnosis and treatment are discussed.•Microneedles for in vivo sampling from living herbs are described.
Editor: China: Elsevier B.V
Idioma: Inglês

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Microneedle-based interstitial fluid extraction for drug analysis: Advances, challenges, and prospects

Ma, Shuwen ; Li, Jiaqi ; Pei, Lixia ; Feng, Nianping ; Zhang, Yongtai

China: Elsevier B.V

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