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Oligonucleotide Adsorption Affects Phase Transition but Not Interdigitation of diC14-Amidine Bilayers

Rozenfeld, Julio H. K ; Duarte, Evandro L ; Oliveira, Tiago R ; Lonez, Caroline ; Ruysschaert, Jean-Marie ; Lamy, M. Teresa

Langmuir, 2013-09, Vol.29 (35), p.11102-11108 [Periódico revisado por pares]

Washington, DC: American Chemical Society

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Título:
Oligonucleotide Adsorption Affects Phase Transition but Not Interdigitation of diC14-Amidine Bilayers
Autor: Rozenfeld, Julio H. K ; Duarte, Evandro L ; Oliveira, Tiago R ; Lonez, Caroline ; Ruysschaert, Jean-Marie ; Lamy, M. Teresa
Assuntos: Adsorption ; Amidines - chemistry ; Chemistry ; DNA, Single-Stranded - chemistry ; Electron Spin Resonance Spectroscopy ; Exact sciences and technology ; General and physical chemistry ; Light ; Liposomes - chemistry ; Oligonucleotides - chemistry ; Phase Transition ; Scattering, Radiation ; Static Electricity ; Surface physical chemistry
É parte de: Langmuir, 2013-09, Vol.29 (35), p.11102-11108
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: In this work, we investigate the effect of a small single-stranded oligonucleotide (ODN) on the colloid stability and structure of cationic diC14-amidine liposomes. Dynamic light scattering (DLS) shows that small, stable, anionic assemblies are formed in presence of excess ODN negative charge. This charge overcompensation condition was further characterized. A less cooperative bilayer phase transition is observed by differential scanning calorimetry (DSC). Electron spin resonance (ESR) spectra of probes at different bilayer depths show that ODN electrostatic adsorption increases the rigidity of both interdigitated gel and lamellar fluid phases. The increase in gel phase rigidity could be explained by the transformation of an adjacent to an interpenetrated interdigitation. Interdigitated fusogenic bilayers may find interesting applications in delivery of therapeutic oligonucleotides.
Editor: Washington, DC: American Chemical Society
Idioma: Inglês

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Oligonucleotide Adsorption Affects Phase Transition but Not Interdigitation of diC14-Amidine Bilayers

Rozenfeld, Julio H. K ; Duarte, Evandro L ; Oliveira, Tiago R ; Lonez, Caroline ; Ruysschaert, Jean-Marie ; Lamy, M. Teresa

Washington, DC: American Chemical Society

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