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Depression of hippocampal low calcium field bursts by the antiepileptic drug valproic acid

Agopyan, N. ; Avoli, M. ; Rieb, L. ; Tancredi, V.

Neuroscience letters, 1985-09, Vol.60 (1), p.57-62 [Periódico revisado por pares]

Shannon: Elsevier Ireland Ltd

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Título:
Depression of hippocampal low calcium field bursts by the antiepileptic drug valproic acid
Autor: Agopyan, N. ; Avoli, M. ; Rieb, L. ; Tancredi, V.
Assuntos: Animals ; Anticonvulsants. Antiepileptics. Antiparkinson agents ; Biological and medical sciences ; Calcium - physiology ; gamma-Aminobutyric Acid - physiology ; Hippocampus - drug effects ; Hippocampus - physiology ; In Vitro Techniques ; Ion Channels - drug effects ; low calcium field burst ; Male ; Medical sciences ; Membrane Potentials - drug effects ; Neuropharmacology ; Pharmacology. Drug treatments ; Rats ; Rats, Inbred Strains ; Synapses - drug effects ; Synaptic Transmission - drug effects ; valproic acid ; Valproic Acid - pharmacology
É parte de: Neuroscience letters, 1985-09, Vol.60 (1), p.57-62
Notas: ObjectType-Article-2
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Descrição: The antiepileptic drug valproic acid (VPA) reduces the occurrence of the rhythmic and synchronous bursts produced by hippocampal neurons maintained ‘in vitro’ and bathed in Ringer-containing low-Ca 2+ (0.2 mM), high-Mg 2+ (4.0 mM). In this medium, synaptic transmission is blocked, thus demonstrating an action of VPA unrelated to potentiation of GABAergic phenomena. This conclusion is reenforced by the persistence of VPA effects in the presence of bicuculline. Also, the VPA doses effective in reducing the low-calcium synchronous burst in the hippocampal slice are similar to the free plasma levels of VPA observed to exert anticonvulsant effects in kindled rats.
Editor: Shannon: Elsevier Ireland Ltd
Idioma: Inglês

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Depression of hippocampal low calcium field bursts by the antiepileptic drug valproic acid

Agopyan, N. ; Avoli, M. ; Rieb, L. ; Tancredi, V.

Shannon: Elsevier Ireland Ltd

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