Idioma:

Treadmill Exercise Induces Hippocampal Astroglial Alterations in Rats

Bernardi, Caren ; Tramontina, Ana Carolina ; Nardin, Patrícia ; Biasibetti, Regina ; Costa, Ana Paula ; Vizueti, Adriana Fernanda ; Batassini, Cristiane ; Tortorelli, Lucas Silva ; Wartchow, Krista Minéia ; Dutra, Márcio Ferreira ; Bobermin, Larissa ; Sesterheim, Patrícia ; Quincozes-Santos, André ; de Souza, Jaqueline ; Gonçalves, Carlos Alberto Baudry, Michel ; Michel Baudry

Journal of neural transplantation & plasticity, 2013-01, Vol.2013, p.709732-10 [Periódico revisado por pares]

United States: Hindawi Limiteds

Texto completo disponível

Citações Citado por

Enviar para

Título:
Treadmill Exercise Induces Hippocampal Astroglial Alterations in Rats
Autor: Bernardi, Caren ; Tramontina, Ana Carolina ; Nardin, Patrícia ; Biasibetti, Regina ; Costa, Ana Paula ; Vizueti, Adriana Fernanda ; Batassini, Cristiane ; Tortorelli, Lucas Silva ; Wartchow, Krista Minéia ; Dutra, Márcio Ferreira ; Bobermin, Larissa ; Sesterheim, Patrícia ; Quincozes-Santos, André ; de Souza, Jaqueline ; Gonçalves, Carlos Alberto
Baudry, Michel ; Michel Baudry
Assuntos: Adaptation ; Animals ; Astrocytes ; Astrocytes - physiology ; Brain ; Brain-derived neurotrophic factor ; Corticosterone - blood ; Exercise ; Exercise Test - methods ; Fitness equipment ; Glucose ; Health aspects ; Hippocampus (Brain) ; Hippocampus - cytology ; Hippocampus - physiology ; Male ; Neurological research ; Neuroplasticity ; Physical Conditioning, Animal - methods ; Physical fitness ; Physiological aspects ; Proteins ; Rats ; Rats, Wistar ; Treadmills (Exercise equipment)
É parte de: Journal of neural transplantation & plasticity, 2013-01, Vol.2013, p.709732-10
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Academic Editor: Michel Baudry
Descrição: Physical exercise effects on brain health and cognitive performance have been described. Synaptic remodeling in hippocampus induced by physical exercise has been described in animal models, but the underlying mechanisms remain poorly understood. Changes in astrocytes, the glial cells involved in synaptic remodeling, need more characterization. We investigated the effect of moderate treadmill exercise (20 min/day) for 4 weeks on some parameters of astrocytic activity in rat hippocampal slices, namely, glial fibrillary acidic protein (GFAP), glutamate uptake and glutamine synthetase (GS) activities, glutathione content, and S100B protein content and secretion, as well as brain-derived neurotrophic factor (BDNF) levels and glucose uptake activity in this tissue. Results show that moderate treadmill exercise was able to induce a decrease in GFAP content (evaluated by ELISA and immunohistochemistry) and an increase in GS activity. These changes could be mediated by corticosterone, whose levels were elevated in serum. BDNF, another putative mediator, was not altered in hippocampal tissue. Moreover, treadmill exercise caused a decrease in NO content. Our data indicate specific changes in astrocyte markers induced by physical exercise, the importance of studying astrocytes for understanding brain plasticity, as well as reinforce the relevance of physical exercise as a neuroprotective strategy.
Editor: United States: Hindawi Limiteds
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Anterior Resultado 4 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Treadmill Exercise Induces Hippocampal Astroglial Alterations in Rats

United States: Hindawi Limiteds

Buscando em bases de dados remotas. Favor aguardar.