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Recent insights into the structure and function of coronavirus ribonucleases

Frazier, Meredith N. ; Riccio, Amanda A. ; Wilson, Isha M. ; Copeland, William C. ; Stanley, Robin E.

FEBS open bio, 2022-09, Vol.12 (9), p.1567-1583 [Periódico revisado por pares]

England: John Wiley & Sons, Inc

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Título:
Recent insights into the structure and function of coronavirus ribonucleases
Autor: Frazier, Meredith N. ; Riccio, Amanda A. ; Wilson, Isha M. ; Copeland, William C. ; Stanley, Robin E.
Assuntos: Coronaviridae ; Coronaviruses ; COVID-19 ; DNA binding proteins ; drug design ; Endonuclease ; endonucleases ; Exonuclease ; exonucleases ; Genetic transcription ; Genomes ; Genomics ; Health aspects ; Humans ; Immune response ; Interferon ; Middle East respiratory syndrome ; Molecular modelling ; Mutation ; Nonstructural proteins ; Nuclease ; Nucleases ; Replication ; Respiratory diseases ; Review ; Reviews ; Ribonucleases ; RNA ; SARS-CoV-2 ; Severe acute respiratory syndrome coronavirus 2 ; structural biology ; Structure-function relationships ; Viral Nonstructural Proteins - chemistry ; Viral Nonstructural Proteins - genetics ; Viral Nonstructural Proteins - metabolism
É parte de: FEBS open bio, 2022-09, Vol.12 (9), p.1567-1583
Notas: Meredith N. Frazier and Amanda A. Riccio contributed equally to this article
Edited by Alexander Wlodawer
Descrição: Coronaviruses use approximately two‐thirds of their 30‐kb genomes to encode nonstructural proteins (nsps) with diverse functions that assist in viral replication and transcription, and evasion of the host immune response. The SARS‐CoV‐2 pandemic has led to renewed interest in the molecular mechanisms used by coronaviruses to infect cells and replicate. Among the 16 Nsps involved in replication and transcription, coronaviruses encode two ribonucleases that process the viral RNA—an exonuclease (Nsp14) and an endonuclease (Nsp15). In this review, we discuss recent structural and biochemical studies of these nucleases and the implications for drug discovery. Coronaviruses encode two ribonucleases: Nsp14, an exonuclease, and Nsp15, an endonuclease. This review covers the latest structures of SARS‐CoV‐2 Nsp14 and Nsp15 and discusses insights into nuclease functions and progress towards therapeutic inhibitors. The viral particle was generated using BioRender.
Editor: England: John Wiley & Sons, Inc
Idioma: Inglês

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Recent insights into the structure and function of coronavirus ribonucleases

Frazier, Meredith N. ; Riccio, Amanda A. ; Wilson, Isha M. ; Copeland, William C. ; Stanley, Robin E.

England: John Wiley & Sons, Inc

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