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Effects of n-3 Polyunsaturated Fatty Acids on Left Ventricular Function and Functional Capacity in Patients With Dilated Cardiomyopathy

Nodari, Savina, MD ; Triggiani, Marco, MD ; Campia, Umberto, MD ; Manerba, Alessandra, MD ; Milesi, Giuseppe, MD ; Cesana, Bruno M., MD ; Gheorghiade, Mihai, MD ; Dei Cas, Livio, MD

Journal of the American College of Cardiology, 2011-02, Vol.57 (7), p.870-879 [Periódico revisado por pares]

New York, NY: Elsevier Inc

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Título:
Effects of n-3 Polyunsaturated Fatty Acids on Left Ventricular Function and Functional Capacity in Patients With Dilated Cardiomyopathy
Autor: Nodari, Savina, MD ; Triggiani, Marco, MD ; Campia, Umberto, MD ; Manerba, Alessandra, MD ; Milesi, Giuseppe, MD ; Cesana, Bruno M., MD ; Gheorghiade, Mihai, MD ; Dei Cas, Livio, MD
Assuntos: Adolescent ; Adult ; Aged ; Biological and medical sciences ; Cardiology ; Cardiology. Vascular system ; Cardiomyopathy ; Cardiomyopathy, Dilated - complications ; Cardiovascular ; Cardiovascular disease ; Colleges & universities ; Diastole - drug effects ; Double-Blind Method ; Drug dosages ; Drug therapy ; Echocardiography ; Exercise Test ; Exercise Tolerance - drug effects ; Fatty acids ; Fatty Acids, Omega-3 - pharmacology ; Fatty Acids, Omega-3 - therapeutic use ; Female ; functional capacity ; Heart ; Heart failure ; Heart Failure - etiology ; Heart Failure - physiopathology ; Hospitalization ; Humans ; Internal Medicine ; Male ; Medical sciences ; Middle Aged ; Mortality ; Multivariate analysis ; Myocarditis. Cardiomyopathies ; n-3 PUFAs ; nonischemic myocardial function ; NYHA functional class ; Prospective Studies ; Pulmonary arteries ; Rodents ; Stroke Volume - drug effects ; Systole - drug effects ; Ventricular Function, Left - drug effects
É parte de: Journal of the American College of Cardiology, 2011-02, Vol.57 (7), p.870-879
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Descrição: Objectives This study was designed to test the effects of n-3 polyunsaturated fatty acids (PUFAs) on left ventricular (LV) systolic function in chronic heart failure (HF) due to nonischemic dilated cardiomyopathy (NICM). Background One hundred thirty-three patients with NICM and minimal symptoms on standard therapy were randomized to 2 g of n-3 PUFAs or placebo. LV function and functional capacity were assessed prospectively by echocardiography and cardiopulmonary exercise testing at baseline and at 12 months after randomization. Methods Patients with chronic HF due to NICM and minimal symptoms while receiving evidence-based therapy were enrolled. LV function and functional capacity were assessed prospectively by echocardiography, cardiopulmonary exercise test, and New York Heart Association functional class at baseline and at 12 months after randomization to either 2 g of n-3 PUFAs or placebo. Results At 12 months after randomization, the n-3 PUFAs group and the placebo group differed significantly (p <0.001) in regard to: 1) LV ejection fraction (increased by 10.4% and decreased by 5.0%, respectively); 2) peak VO2 (increased by 6.2% and decreased by 4.5%, respectively); 3) exercise duration (increased by 7.5% and decreased by 4.8%, respectively); and 4) mean New York Heart Association functional class (decreased from 1.88 ± 0.33 to 1.61 ± 0.49 and increased from 1.83 ± 0.38 to 2.14 ± 0.65, respectively). The hospitalization rates for HF were 6% in the n-3 PUFAs and 30% in the placebo group (p = 0.0002). Conclusions In patients with NICM and minimal symptoms in response to evidence-based medical therapy, n-3 PUFAs treatment increases LV systolic function and functional capacity and may reduce hospitalizations for HF. Given these promising results, larger studies are in order to confirm our findings.
Editor: New York, NY: Elsevier Inc
Idioma: Inglês

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Effects of n-3 Polyunsaturated Fatty Acids on Left Ventricular Function and Functional Capacity in Patients With Dilated Cardiomyopathy

Nodari, Savina, MD ; Triggiani, Marco, MD ; Campia, Umberto, MD ; Manerba, Alessandra, MD ; Milesi, Giuseppe, MD ; Cesana, Bruno M., MD ; Gheorghiade, Mihai, MD ; Dei Cas, Livio, MD

New York, NY: Elsevier Inc

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