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Green Antimicrobials as Therapeutic Agents for Diabetic Foot Ulcers

Teixeira, Ines D ; Carvalho, Eugenia ; Leal, Ermelindo C

Antibiotics (Basel), 2023-02, Vol.12 (3), p.467 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Green Antimicrobials as Therapeutic Agents for Diabetic Foot Ulcers
Autor: Teixeira, Ines D ; Carvalho, Eugenia ; Leal, Ermelindo C
Assuntos: Antibiotics ; Antimicrobial agents ; Antimicrobial peptides ; Antimicrobial resistance ; antimicrobials peptides ; Bacteria ; Bacterial infections ; Biofilms ; Climate change ; Clinical outcomes ; Complications ; Cytokines ; Diabetes ; Diabetes mellitus ; Diabetic foot ; diabetic foot ulcer ; Diabetics ; Drug resistance in microorganisms ; environmentally friendly ; Foot diseases ; Fungi ; Global health ; Gram-positive bacteria ; green synthesis ; Health aspects ; Health risks ; Immune system ; Infection ; Infections ; Inflammation ; Innate immunity ; Leg ulcers ; Methicillin ; Microorganisms ; Neutrophils ; Pathogens ; Patients ; Peptides ; Peripheral neuropathy ; Pharmacology ; Public health ; Quality of life ; Review ; Skin ; Tissue engineering ; Trauma ; Ulcers ; Wound healing
É parte de: Antibiotics (Basel), 2023-02, Vol.12 (3), p.467
Notas: ObjectType-Article-2
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Descrição: Diabetic foot ulcers (DFU) are one of the most serious and devastating complications of diabetes and account for a significant decrease in quality of life and costly healthcare expenses worldwide. This condition affects around 15% of diabetic patients and is one of the leading causes of lower limb amputations. DFUs generally present poor clinical outcomes, mainly due to the impaired healing process and the elevated risk of microbial infections which leads to tissue damage. Nowadays, antimicrobial resistance poses a rising threat to global health, thus hampering DFU treatment and care. Faced with this reality, it is pivotal to find greener and less environmentally impactful alternatives for fighting these resistant microbes. Antimicrobial peptides are small molecules that play a crucial role in the innate immune system of the host and can be found in nature. Some of these molecules have shown broad-spectrum antimicrobial properties and wound-healing activity, making them good potential therapeutic compounds to treat DFUs. This review aims to describe antimicrobial peptides derived from green, eco-friendly processes that can be used as potential therapeutic compounds to treat DFUs, thereby granting a better quality of life to patients and their families while protecting our fundamental bio-resources.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Green Antimicrobials as Therapeutic Agents for Diabetic Foot Ulcers

Teixeira, Ines D ; Carvalho, Eugenia ; Leal, Ermelindo C

Switzerland: MDPI AG

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