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ALTercations at telomeres: stress, recombination and extrachromosomal affairs

Loe, Taylor K ; Lazzerini Denchi, Eros ; Tricola, Gianna M. ; Azeroglu, Benura

Biochemical Society transactions, 2023-10, Vol.51 (5), p.1935-1946 [Periódico revisado por pares]

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Título:
ALTercations at telomeres: stress, recombination and extrachromosomal affairs
Autor: Loe, Taylor K ; Lazzerini Denchi, Eros ; Tricola, Gianna M. ; Azeroglu, Benura
É parte de: Biochemical Society transactions, 2023-10, Vol.51 (5), p.1935-1946
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Approximately 15% of human cancers depend on the alternative lengthening of telomeres (ALT) pathway to maintain telomeres and proliferate. Telomeres that are elongated using ALT display unique features raising the exciting prospect of tailored cancer therapies. ALT-mediated telomere elongation shares several features with recombination-based DNA repair. Strikingly, cells that use the ALT pathway display abnormal levels of replication stress at telomeres and accumulate abundant extrachromosomal telomeric DNA. In this review, we examine recent findings that shed light on the ALT mechanisms and the strategies currently available to suppress this telomere elongation mechanism.
Idioma: Inglês

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