Idioma:

Homocysteine, methylenetetrahydrofolate reductase and risk of schizophrenia: a meta-analysis

Muntjewerff, J W ; Kahn, R S ; Blom, H J ; den Heijer, M

Molecular psychiatry, 2006-02, Vol.11 (2), p.143-149 [Periódico revisado por pares]

England: Nature Publishing Group

Texto completo disponível

Citações Citado por

Enviar para

Título:
Homocysteine, methylenetetrahydrofolate reductase and risk of schizophrenia: a meta-analysis
Autor: Muntjewerff, J W ; Kahn, R S ; Blom, H J ; den Heijer, M
Assuntos: Amino Acid Substitution ; Case-Control Studies ; Enzymatic activity ; Epidemiology ; Gene polymorphism ; Genetic diversity ; Genetic Predisposition to Disease ; Genotype & phenotype ; Homocysteine ; Homocysteine - blood ; Humans ; Mental disorders ; Meta-analysis ; Metabolism ; Methylenetetrahydrofolate reductase ; Methylenetetrahydrofolate Reductase (NADPH2) - genetics ; Methylenetetrahydrofolate Reductase (NADPH2) - metabolism ; Polymorphism ; Reference Values ; Risk Factors ; Schizophrenia ; Schizophrenia - blood ; Schizophrenia - enzymology ; Schizophrenia - genetics ; Systematic review
É parte de: Molecular psychiatry, 2006-02, Vol.11 (2), p.143-149
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-Review-3
content type line 23
Descrição: Elevated plasma homocysteine concentration has been suggested as a risk factor for schizophrenia, but the results of epidemiological studies have been inconsistent. The most extensively studied genetic variant in the homocysteine metabolism is the 677C>T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene, resulting in reduced enzyme activity and, subsequently, in elevated homocysteine. A meta-analysis of eight retrospective studies (812 cases and 2113 control subjects) was carried out to examine the association between homocysteine and schizophrenia. In addition, a meta-analysis of 10 studies (2265 cases and 2721 control subjects) on the homozygous (TT) genotype of the MTHFR 677C>T polymorphism was carried out to assess if this association is causal. A 5 micromol/l higher homocysteine level was associated with a 70% (95% confidence interval, CI: 27-129) higher risk of schizophrenia. The TT genotype was associated with a 36% (95% CI: 7-72) higher risk of schizophrenia compared to the CC genotype. The performed meta-analyses showed no evidence of publication bias or excessive influence attributable to any given study. In conclusion, our study provides evidence for an association of homocysteine with schizophrenia. The elevated risk of schizophrenia associated with the homozygous genotype of the MTHFR 677C>T polymorphism provides support for causality between a disturbed homocysteine metabolism and risk of schizophrenia.
Editor: England: Nature Publishing Group
Idioma: Inglês

Links

View this record in MEDLINE/PubMed

Voltar para lista de resultados

Anterior Resultado 9 Avançar Ir para próxima página

Realização: Logos de Redes Sociais:

Homocysteine, methylenetetrahydrofolate reductase and risk of schizophrenia: a meta-analysis

Muntjewerff, J W ; Kahn, R S ; Blom, H J ; den Heijer, M

England: Nature Publishing Group

Buscando em bases de dados remotas. Favor aguardar.