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Dispensability of Surfactant Proteins A and D in Immune Control of Mycobacterium tuberculosis Infection following Aerosol Challenge of Mice

Lemos, Maria P ; McKinney, John ; Rhee, Kyu Y Flynn, J. L.

Infection and Immunity, 2011-03, Vol.79 (3), p.1077-1085 [Periódico revisado por pares]

Washington, DC: American Society for Microbiology

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Título:
Dispensability of Surfactant Proteins A and D in Immune Control of Mycobacterium tuberculosis Infection following Aerosol Challenge of Mice
Autor: Lemos, Maria P ; McKinney, John ; Rhee, Kyu Y
Flynn, J. L.
Assuntos: Animals ; Bacteriology ; Biological and medical sciences ; CD4-Positive T-Lymphocytes - immunology ; Cell Separation ; Disease Models, Animal ; Flow Cytometry ; Fundamental and applied biological sciences. Psychology ; Host Response and Inflammation ; Macrophages - immunology ; Mice ; Mice, Knockout ; Microbiology ; Miscellaneous ; Mycobacterium tuberculosis ; Mycobacterium tuberculosis - immunology ; Pulmonary Surfactant-Associated Protein A - deficiency ; Pulmonary Surfactant-Associated Protein A - immunology ; Pulmonary Surfactant-Associated Protein A - metabolism ; Pulmonary Surfactant-Associated Protein D - deficiency ; Pulmonary Surfactant-Associated Protein D - immunology ; Pulmonary Surfactant-Associated Protein D - metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Tuberculosis, Pulmonary - immunology ; Tuberculosis, Pulmonary - metabolism ; Tuberculosis, Pulmonary - pathology
É parte de: Infection and Immunity, 2011-03, Vol.79 (3), p.1077-1085
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Present address: Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N., D3-100, Seattle, WA 98109.
Editor: J. L. Flynn
Present address: EPFL-FSV-GHI, Bâtiment AI 2150, Station 15, 1015 Lausanne, Switzerland.
Descrição: Surfactant proteins A and D (SP-A and -D) play a role in many acute bacterial, viral, and fungal infections and in acute allergic responses. In vitro, human SPs bind Mycobacterium tuberculosis and alter human and rat macrophage-mediated functions. Here we report the roles of SP-A and SP-D in M. tuberculosis infection following aerosol challenge of SP-A-, SP-D-, and SP-A/-D-deficient mice. These studies surprisingly identified no gross defects in uptake or immune control of M. tuberculosis in SP-A-, SP-D-, and SP-A/-D-deficient mice. While both SP-A- and SP-D-deficient mice exhibited evidence of immunopathologic defects, the CD11bhigh CD11chigh dendritic cell populations and the gamma interferon (IFN-γ)-dependent CD4⁺ T cell response to M. tuberculosis were unaltered in all genotypes tested. Together, these data indicate that SP-A and SP-D are dispensable for immune control of M. tuberculosis in a low-dose, aerosol challenge, murine model of tuberculosis (TB).
Editor: Washington, DC: American Society for Microbiology
Idioma: Inglês

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Dispensability of Surfactant Proteins A and D in Immune Control of Mycobacterium tuberculosis Infection following Aerosol Challenge of Mice

Lemos, Maria P ; McKinney, John ; Rhee, Kyu Y Flynn, J. L.

Washington, DC: American Society for Microbiology

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