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Microglia-glioblastoma interactions: New role for Wnt signaling

Matias, D. ; Predes, D. ; Niemeyer Filho, P. ; Lopes, M.C. ; Abreu, J.G. ; Lima, F.R.S. ; Moura Neto, V.

Biochimica et biophysica acta. Reviews on cancer, 2017-08, Vol.1868 (1), p.333-340 [Periódico revisado por pares]

Netherlands: Elsevier B.V

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Título:
Microglia-glioblastoma interactions: New role for Wnt signaling
Autor: Matias, D. ; Predes, D. ; Niemeyer Filho, P. ; Lopes, M.C. ; Abreu, J.G. ; Lima, F.R.S. ; Moura Neto, V.
Assuntos: Animals ; Brain macrophages ; Brain Neoplasms - metabolism ; Brain Neoplasms - pathology ; Cytokines - metabolism ; Glioblastoma ; Glioblastoma - metabolism ; Glioblastoma - pathology ; Gliomas ; Humans ; Intercellular Signaling Peptides and Proteins - metabolism ; Microglia ; Microglia - metabolism ; Microglia - pathology ; Wnt pathway ; Wnt Signaling Pathway - physiology
É parte de: Biochimica et biophysica acta. Reviews on cancer, 2017-08, Vol.1868 (1), p.333-340
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Glioblastoma, the most aggressive and fatal type of brain tumor, is capable of interacting with brain immune cells such as microglia, which contributes to the growth of these tumors. Various molecules, including growth factors and cytokines, have been identified as regulators of microglia-glioblastoma interaction. Recent studies suggest that the Wnt family of lipoglycoproteins plays an important role, not only in biological events during development, but also in cancer progression, and can be part of microglia recruitment to glioblastoma as well as of tumor growth and invasion. Here, we discuss recent interesting findings that support a role for Wnt signaling pathways in the microglia-glioblastoma crosstalk.
Editor: Netherlands: Elsevier B.V
Idioma: Inglês

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Microglia-glioblastoma interactions: New role for Wnt signaling

Matias, D. ; Predes, D. ; Niemeyer Filho, P. ; Lopes, M.C. ; Abreu, J.G. ; Lima, F.R.S. ; Moura Neto, V.

Netherlands: Elsevier B.V

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