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NAD + cleavage activity by animal and plant TIR domains in cell death pathways

Horsefield, Shane ; Burdett, Hayden ; Zhang, Xiaoxiao ; Manik, Mohammad K ; Shi, Yun ; Chen, Jian ; Qi, Tiancong ; Gilley, Jonathan ; Lai, Jhih-Siang ; Rank, Maxwell X ; Casey, Lachlan W ; Gu, Weixi ; Ericsson, Daniel J ; Foley, Gabriel ; Hughes, Robert O ; Bosanac, Todd ; von Itzstein, Mark ; Rathjen, John P ; Nanson, Jeffrey D ; Boden, Mikael ; Dry, Ian B ; Williams, Simon J ; Staskawicz, Brian J ; Coleman, Michael P ; Ve, Thomas ; Dodds, Peter N ; Kobe, Bostjan

Science (American Association for the Advancement of Science), 2019-08, Vol.365 (6455), p.793-799 [Periódico revisado por pares]

United States: The American Association for the Advancement of Science

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Título:
NAD + cleavage activity by animal and plant TIR domains in cell death pathways
Autor: Horsefield, Shane ; Burdett, Hayden ; Zhang, Xiaoxiao ; Manik, Mohammad K ; Shi, Yun ; Chen, Jian ; Qi, Tiancong ; Gilley, Jonathan ; Lai, Jhih-Siang ; Rank, Maxwell X ; Casey, Lachlan W ; Gu, Weixi ; Ericsson, Daniel J ; Foley, Gabriel ; Hughes, Robert O ; Bosanac, Todd ; von Itzstein, Mark ; Rathjen, John P ; Nanson, Jeffrey D ; Boden, Mikael ; Dry, Ian B ; Williams, Simon J ; Staskawicz, Brian J ; Coleman, Michael P ; Ve, Thomas ; Dodds, Peter N ; Kobe, Bostjan
Assuntos: Adenine ; Animals ; Apoptosis ; Armadillo Domain Proteins - chemistry ; Armadillo Domain Proteins - metabolism ; Axons - enzymology ; Axons - pathology ; Binding Sites ; Cell Death ; Cleavage ; Conserved Sequence ; Crystal structure ; Crystallography, X-Ray ; Cytokines ; Cytoskeletal Proteins - chemistry ; Cytoskeletal Proteins - metabolism ; Degeneration ; Depletion ; Enzymatic activity ; HEK293 Cells ; Humans ; Hypersensitive response ; Infections ; Interleukin 1 ; Leucine ; Literary Devices ; Mice ; Mortality ; NAD - metabolism ; NAD+ Nucleosidase - chemistry ; NAD+ Nucleosidase - metabolism ; NADP ; NADP - metabolism ; NADPH-diaphorase ; Neurodegeneration ; Neurons - enzymology ; Neuropathy ; Nicotinamide ; Nicotinamide adenine dinucleotide ; Nucleotides ; Pathogens ; Plant Proteins - chemistry ; Plant Proteins - metabolism ; Protein Domains ; Protein Multimerization ; Proteins ; Receptors ; Receptors, Immunologic - chemistry ; Receptors, Immunologic - metabolism ; Ribose ; Self-association ; Signal transduction ; Signaling ; Substrates ; Wallerian Degeneration - enzymology ; Wallerian Degeneration - pathology
É parte de: Science (American Association for the Advancement of Science), 2019-08, Vol.365 (6455), p.793-799
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: SARM1 (sterile alpha and TIR motif containing 1) is responsible for depletion of nicotinamide adenine dinucleotide in its oxidized form (NAD ) during Wallerian degeneration associated with neuropathies. Plant nucleotide-binding leucine-rich repeat (NLR) immune receptors recognize pathogen effector proteins and trigger localized cell death to restrict pathogen infection. Both processes depend on closely related Toll/interleukin-1 receptor (TIR) domains in these proteins, which, as we show, feature self-association-dependent NAD cleavage activity associated with cell death signaling. We further show that SARM1 SAM (sterile alpha motif) domains form an octamer essential for axon degeneration that contributes to TIR domain enzymatic activity. The crystal structures of ribose and NADP (the oxidized form of nicotinamide adenine dinucleotide phosphate) complexes of SARM1 and plant NLR RUN1 TIR domains, respectively, reveal a conserved substrate binding site. NAD cleavage by TIR domains is therefore a conserved feature of animal and plant cell death signaling pathways.
Editor: United States: The American Association for the Advancement of Science
Idioma: Inglês

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NAD + cleavage activity by animal and plant TIR domains in cell death pathways

United States: The American Association for the Advancement of Science

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