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Local translation in neurons: visualization and function

Holt, Christine E ; Martin, Kelsey C ; Schuman, Erin M

Nature structural & molecular biology, 2019-07, Vol.26 (7), p.557-566 [Periódico revisado por pares]

United States: Nature Publishing Group

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Título:
Local translation in neurons: visualization and function
Autor: Holt, Christine E ; Martin, Kelsey C ; Schuman, Erin M
Assuntos: Animals ; Axon guidance ; Axons ; Composition ; Dendrites ; Functionals ; Genetic translation ; Humans ; Microscopy ; Neurons ; Neurons - cytology ; Neurons - metabolism ; Neurons - ultrastructure ; Physiological aspects ; Protein Biosynthesis ; Protein Processing, Post-Translational ; Protein research ; Protein sources ; Protein synthesis ; Proteins ; Proteomes ; Ribosomes - genetics ; Ribosomes - ultrastructure ; RNA, Messenger - analysis ; RNA, Messenger - genetics ; Synapses ; Translation ; Visualization
É parte de: Nature structural & molecular biology, 2019-07, Vol.26 (7), p.557-566
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Descrição: Neurons are among the most compartmentalized and interactive of all cell types. Like all cells, neurons use proteins as the main sensors and effectors. The modification of the proteome in axons and dendrites is used to guide the formation of synaptic connections and to store information. In this Review, we discuss the data indicating that an important source of protein for dendrites, axons and their associated elements is provided by the local synthesis of proteins. We review the data indicating the presence of the machinery required for protein synthesis, the direct visualization and demonstration of protein synthesis, and the established functional roles for local translation for many different neuronal functions. Finally, we consider the open questions and future directions in this field.
Editor: United States: Nature Publishing Group
Idioma: Inglês

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Local translation in neurons: visualization and function

Holt, Christine E ; Martin, Kelsey C ; Schuman, Erin M

United States: Nature Publishing Group

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