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Histopathological Correlates of Global and Segmental Left Ventricular Systolic Dysfunction in Experimental Chronic Chagas Cardiomyopathy

Oliveira, Luciano Fonseca Lemos ; Romano, Minna Moreira Dias ; Carvalho, Eduardo Elias Vieira ; Mejia Cabeza, Jorge ; Salgado, Hélio Cesar ; Fazan Júnior, Rubens ; Costa, Renata Sesti ; Silva, João Santana ; Lourdes Higuchi, Maria ; Maciel, Benedito Carlos ; Cunha‐Neto, Edécio ; Marin‐Neto, José Antônio ; Simões, Marcus Vinícius

Journal of the American Heart Association, 2016-01, Vol.5 (1), p.n/a [Revista revisada por pares]

England: John Wiley and Sons Inc

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Título:
Histopathological Correlates of Global and Segmental Left Ventricular Systolic Dysfunction in Experimental Chronic Chagas Cardiomyopathy
Autor: Oliveira, Luciano Fonseca Lemos ; Romano, Minna Moreira Dias ; Carvalho, Eduardo Elias Vieira ; Mejia Cabeza, Jorge ; Salgado, Hélio Cesar ; Fazan Júnior, Rubens ; Costa, Renata Sesti ; Silva, João Santana ; Lourdes Higuchi, Maria ; Maciel, Benedito Carlos ; Cunha‐Neto, Edécio ; Marin‐Neto, José Antônio ; Simões, Marcus Vinícius
Materias: Animals ; Chagas Cardiomyopathy - diagnostic imaging ; Chagas Cardiomyopathy - parasitology ; Chagas Cardiomyopathy - pathology ; Chagas Cardiomyopathy - physiopathology ; Chagas heart failure ; Chronic Disease ; Disease Models, Animal ; echocardiography ; Echocardiography, Doppler ; Female ; Fibrosis ; Mesocricetus ; Myocardium - pathology ; Original Research ; pathology ; Stroke Volume ; Systole ; Time Factors ; Trypanosoma cruzi - pathogenicity ; Ventricular Dysfunction, Left - diagnostic imaging ; Ventricular Dysfunction, Left - parasitology ; Ventricular Dysfunction, Left - pathology ; Ventricular Dysfunction, Left - physiopathology ; Ventricular Function, Left ; Ventricular Remodeling
Es parte de: Journal of the American Heart Association, 2016-01, Vol.5 (1), p.n/a
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descripción: Background Chronic Chagas cardiomyopathy in humans is characterized by segmental left ventricular wall motion abnormalities (WMA), mainly in the early stages of disease. This study aimed at investigating the detection of WMA and its correlation with the underlying histopathological changes in a chronic Chagas cardiomyopathy model in hamsters. Methods and Results Female Syrian hamsters (n=34) infected with 3.5×104 or 105 blood trypomastigote Trypanosoma cruzi (Y strain) forms and an uninfected control group (n=7) were investigated. After 6 or 10 months after the infection, the animals were submitted to in vivo evaluation of global and segmental left ventricular systolic function by echocardiography, followed by euthanasia and histological analysis for quantitative assessment of fibrosis and inflammation with tissue sampling in locations coinciding with the left ventricular wall segmentation employed at the in vivo echocardiographic evaluation. Ten of the 34 infected animals (29%) showed reduced left ventricular ejection fraction (<73%). Left ventricular ejection fraction was more negatively correlated with the intensity of inflammation (r=−0.63; P<0.0001) than with the extent of fibrosis (r=−0.36; P=0.036). Among the 24 animals with preserved left ventricular ejection fraction (82.9±5.5%), 8 (33%) showed segmental WMA predominating in the apical, inferior, and posterolateral segments. The segments exhibiting WMA, in comparison to those with normal wall motion, showed a greater extent of fibrosis (9.3±5.7% and 7±6.3%, P<0.0001) and an even greater intensity of inflammation (218.0±111.6 and 124.5±84.8 nuclei/mm², P<0.0001). Conclusions Isolated WMA with preserved global systolic left ventricular function is frequently found in Syrian hamsters with experimental chronic Chagas cardiomyopathy whose underlying histopathological features are mainly inflammatory.
Editor: England: John Wiley and Sons Inc
Idioma: Inglés

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Histopathological Correlates of Global and Segmental Left Ventricular Systolic Dysfunction in Experimental Chronic Chagas Cardiomyopathy

England: John Wiley and Sons Inc

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