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1,2-Benzenedithiole-Based Cyclocondensation Assay: A Valuable Tool for the Measurement of Chemopreventive Isothiocyanates

Zhang, Yuesheng

Critical reviews in food science and nutrition, 2012-06, Vol.52 (6), p.525-532 [Periódico revisado por pares]

Philadelphia, PA: Taylor & Francis Group

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Título:
1,2-Benzenedithiole-Based Cyclocondensation Assay: A Valuable Tool for the Measurement of Chemopreventive Isothiocyanates
Autor: Zhang, Yuesheng
Assuntos: Antineoplastic Agents, Phytogenic - chemistry ; Antineoplastic Agents, Phytogenic - pharmacology ; Biological and medical sciences ; Cancer ; chemoprevention ; cruciferous vegetable ; Diet ; diet and cancer prevention ; Feeding. Feeding behavior ; Food Analysis - methods ; Food industries ; Fruit and vegetable industries ; Functional foods & nutraceuticals ; Fundamental and applied biological sciences. Psychology ; Humans ; isothiocyanate quantitation ; isothiocyanates ; Isothiocyanates - chemistry ; Isothiocyanates - pharmacology ; mechanism of action ; Metabolites ; phytochemical ; Sensitivity and Specificity ; Sulfhydryl Compounds - chemistry ; Vegetables ; Vertebrates: anatomy and physiology, studies on body, several organs or systems
É parte de: Critical reviews in food science and nutrition, 2012-06, Vol.52 (6), p.525-532
Notas: http://dx.doi.org/10.1080/10408398.2010.503288
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Descrição: Many naturally occurring isothiocyanates (ITCs) show highly promising chemopreventive activities. Humans are commonly exposed to these compounds through the consumption of cruciferous vegetables which are the main source of dietary ITCs. Dietary ITCs may play an important role in cancer prevention and in the well-recognized cancer preventive activities of cruciferous vegetables. A generic analytical method, namely the 1,2-benzenedithiol-based cyclocondensation assay, was previously developed for quantitation of ITCs and their in vivo metabolites. This method has been widely used and has contributed greatly to research on chemoprevention by ITCs. In this article, the discovery and development of the cyclocondensation assay are recapitulated, and its sensitivity and specificity as well as its advantages and limitations are scrutinized. Moreover, detailed discussion is also provided to show how this assay has been used to advance our understanding of the cancer chemopreventive potential and the mechanism of action of ITCs.
Editor: Philadelphia, PA: Taylor & Francis Group
Idioma: Inglês

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1,2-Benzenedithiole-Based Cyclocondensation Assay: A Valuable Tool for the Measurement of Chemopreventive Isothiocyanates

Zhang, Yuesheng

Philadelphia, PA: Taylor & Francis Group

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