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Relationship between diet and anticoagulant response to warfarin a factor analysis

Silvia Maria Custódio das Dôres Sarah L Booth; Lígia Araújo Martini; Victor Hugo de Carvalho Gouvêa; Carlos Roberto Padovani; Francisco Humberto de Abreu Maffei; Álvaro Oscar Campana; Sérgio Alberto Rupp de Paiva

European Journal of Nutrition Darmstadt v. 46, n. 3, p. 147-154, 2007

Darmstadt 2007

Localização: FSP - Faculdade de Saúde Pública    (HNT-08/2007 )(Acessar)

  • Título:
    Relationship between diet and anticoagulant response to warfarin a factor analysis
  • Autor: Silvia Maria Custódio das Dôres
  • Sarah L Booth; Lígia Araújo Martini; Victor Hugo de Carvalho Gouvêa; Carlos Roberto Padovani; Francisco Humberto de Abreu Maffei; Álvaro Oscar Campana; Sérgio Alberto Rupp de Paiva
  • Assuntos: VITAMINA K; COMPOSTOS HETEROCÍCLICOS; ANTICOAGULANTES; FABACEAE; DIETA; DOENÇAS VASCULARES (METABOLISMO)
  • É parte de: European Journal of Nutrition Darmstadt v. 46, n. 3, p. 147-154, 2007
  • Descrição: Background: Diet composition is one of the factors that may contribute to intraindividual variability in the anticoagulant response to warfarin. Aim of the study To determine the associations between food pattern and anticoagulant response to warfarin in a group of Brazilian patients with vascular disease. Methods: Recent and usual food intakes were assessed in 115 patients receiving warfarin; and corresponding plasma phylloquinone (vitamin K1), serum triglyceride concentrations, prothrombin time (PT), and International Normalized Ratio (INR) were determined. A factor analysis was used to examine the association of specific foods and biochemical variables with anticoagulant data. Results: Mean age was 59 ± 15 years. Inadequate anticoagulation, defined as values of INR 2 or 3, was found in 48 percent of the patients. Soybean oil and kidney beans were the primary food sources of phylloquinone intake. Factor analysis yielded four separate factors, explaining 56.4 percent of the total variance in the data set. The factor analysis revealed that intakes of kidney beans and soybean oil, 24-h recall of phylloquinone intake, PT and INR loaded significantly on factor 1. Triglycerides, PT, INR, plasma phylloquinone, and duration of anticoagulation therapy loaded on factor 3. Conclusions: Fluctuations in phylloquinone intake, particularly from kidney beans, and plasma phylloquinone concentrations were associated with variation in measures of anticoagulation (PT
    and INR) in a Brazilian group of patients with vascular disease
  • Editor: Darmstadt
  • Data de criação/publicação: 2007
  • Formato: p. 147-154.
  • Idioma: Inglês
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  • Realização: ABCD-USP USP   Logos de Redes Sociais: Freepik

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