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An analysis of morphological, cytochemical, immunological and clinical features of adult T cell acute lymphoblastic leukemia
Ferrara, F ; Del Vecchio, L ; Fasanaro, A ; Rametta, V ; Ronconi, F ; Montuori, R
Ricerca in clinica e in laboratorio, 1988-01, Vol.18 (1), p.45-51
Italy
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Título:
An analysis of morphological, cytochemical, immunological and clinical features of adult T cell acute lymphoblastic leukemia
Autor:
Ferrara, F
;
Del Vecchio, L
;
Fasanaro, A
;
Rametta, V
;
Ronconi, F
;
Montuori, R
Assuntos:
Adult
;
Alkaline Phosphatase - metabolism
;
Antigens, Differentiation, T-Lymphocyte
;
Antigens, Neoplasm
;
B-Lymphocytes
;
Female
;
Histocytochemistry
;
Humans
;
Leukemia, Lymphoid - immunology
;
Leukemia, Lymphoid - metabolism
;
Leukemia, Lymphoid - pathology
;
Male
;
Periodic Acid-Schiff Reaction
;
T-Lymphocytes - immunology
;
T-Lymphocytes - metabolism
;
T-Lymphocytes - pathology
É parte de:
Ricerca in clinica e in laboratorio, 1988-01, Vol.18 (1), p.45-51
Notas:
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição:
Morphological, cytochemical, immunological and clinical features of 19 adult patients with T cell acute lymphoblastic leukemia (T-ALL) were investigated at the time of diagnosis and were compared with those of 34 adult patients affected by B cell acute lymphoblastic leukemia (B-ALL). Immunophenotypic studies employing a wide panel of monoclonal antibodies (mAbs) revealed a heterogeneous pattern of antigen expression in the five T-ALL groups that were identified on the basis of blast T cell differentiation levels. PAS (periodic acid Schiff) negativity and focal AP (acid phosphatase) positivity, as well as white blood cell count and serum lactic dehydrogenase levels, were significantly related to T-ALL when compared with B-ALL. On the contrary, no statistically significant difference was demonstrated in the clinical outcome.
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Italy
Idioma:
Inglês
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