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Transplantation of bone marrow mononuclear cells decreases seizure incidence, mitigates neuronal loss and modulates pro-inflammatory cytokine production in epileptic rats

Costa-Ferro, Zaquer S.M ; Souza, Bruno S.F ; Leal, Marcos M.T ; Kaneto, Carla Martins ; Azevedo, Carine Machado ; da Silva, Igor Campos ; Soares, Milena B.P ; Ribeiro-dos-Santos, Ricardo ; DaCosta, Jaderson C

Neurobiology of disease, 2012-05, Vol.46 (2), p.302-313 [Periódico revisado por pares]

United States: Elsevier Inc

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Título:
Transplantation of bone marrow mononuclear cells decreases seizure incidence, mitigates neuronal loss and modulates pro-inflammatory cytokine production in epileptic rats
Autor: Costa-Ferro, Zaquer S.M ; Souza, Bruno S.F ; Leal, Marcos M.T ; Kaneto, Carla Martins ; Azevedo, Carine Machado ; da Silva, Igor Campos ; Soares, Milena B.P ; Ribeiro-dos-Santos, Ricardo ; DaCosta, Jaderson C
Assuntos: Allografts ; Animals ; Anticonvulsants ; Antiepileptic agents ; Bone marrow ; Bone marrow mononuclear cells ; Bone marrow transplantation ; Bone Marrow Transplantation - methods ; Bone Marrow Transplantation - pathology ; Brain ; Cell Movement - physiology ; Cytokines ; Cytokines - biosynthesis ; Data processing ; Epilepsy ; Epilepsy - metabolism ; Epilepsy - pathology ; Epilepsy - surgery ; Gliosis ; Incidence ; Inflammation ; Inflammation Mediators - metabolism ; Interleukin 1 ; Interleukin 10 ; Interleukin 6 ; Leukocytes (mononuclear) ; Leukocytes, Mononuclear - pathology ; Leukocytes, Mononuclear - transplantation ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Nervous system ; Neurology ; Neuronal loss ; Neurons ; Neurons - metabolism ; Neurons - pathology ; Pilocarpine ; Rats ; Rats, Wistar ; Seizure frequency ; Seizures ; Temporal lobe ; Temporal lobe epilepsy ; Transplantation ; Transplants ; Tumor necrosis factor- alpha
É parte de: Neurobiology of disease, 2012-05, Vol.46 (2), p.302-313
Notas: ObjectType-Article-2
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Descrição: Abstract Approximately 30% of patients with mesial temporal lobe epilepsy do not respond to treatment with antiepileptic drugs. We have previously shown that transplantation of mononuclear bone marrow cells (BMC) has an anticonvulsant effect in acute epilepsy. Here, we used pilocarpine to induce epilepsy in rats and studied the effects of BMC injected intravenously either at the onset of seizures or after 10 months of recurrent seizures. BMC effectively decreased seizure frequency and duration. In addition, decreased levels of proinflammatory cytokines (TNF-α, IL-1β and IL-6) and increased levels of anti-inflammatory cytokine (IL-10) were observed in the brain and serum of BMC-treated rats. Transplants performed at seizure-onset protected against pilocarpine-induced neuronal loss and gliosis and stimulated the proliferation of new neurons in epileptic rats. Our data demonstrate that BMC transplantation has potent therapeutic effects and could be a potential therapy for clinically intractable epilepsies.
Editor: United States: Elsevier Inc
Idioma: Inglês

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Transplantation of bone marrow mononuclear cells decreases seizure incidence, mitigates neuronal loss and modulates pro-inflammatory cytokine production in epileptic rats

Costa-Ferro, Zaquer S.M ; Souza, Bruno S.F ; Leal, Marcos M.T ; Kaneto, Carla Martins ; Azevedo, Carine Machado ; da Silva, Igor Campos ; Soares, Milena B.P ; Ribeiro-dos-Santos, Ricardo ; DaCosta, Jaderson C

United States: Elsevier Inc

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