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Uniquely altered transcripts are associated with immune preservation in HIV infection

Zanoni, Michelle ; Aventurato, Ítalo Karmann ; Hunter, James ; Sucupira, Maria Cecilia Araripe ; Diaz, Ricardo Sobhie Poli, Guido

PloS one, 2017-03, Vol.12 (3), p.e0169868-e0169868 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
Uniquely altered transcripts are associated with immune preservation in HIV infection
Autor: Zanoni, Michelle ; Aventurato, Ítalo Karmann ; Hunter, James ; Sucupira, Maria Cecilia Araripe ; Diaz, Ricardo Sobhie
Poli, Guido
Assuntos: Antiretroviral agents ; Antiretroviral Therapy, Highly Active ; Antithrombin III - genetics ; Antithrombin III - immunology ; Antiviral Agents - therapeutic use ; Binding sites ; Biology and Life Sciences ; Bone marrow ; Brazil ; Care and treatment ; CD4 Lymphocyte Count ; Chemokines - genetics ; Chemokines - immunology ; Cohort Studies ; Control ; Controllers ; Cross-Priming - immunology ; Cytokines ; Cytokines - genetics ; Cytokines - immunology ; Elastase ; Gene expression ; Gene Expression Profiling - methods ; Health aspects ; Highly active antiretroviral therapy ; HIV ; HIV infection ; HIV infections ; HIV Infections - drug therapy ; HIV Infections - genetics ; HIV Infections - immunology ; HIV Long-Term Survivors ; HIV-1 - drug effects ; HIV-1 - immunology ; HLA-B Antigens - immunology ; Host-Pathogen Interactions - drug effects ; Host-Pathogen Interactions - immunology ; Human immunodeficiency virus ; Humans ; Immunology ; Infections ; Inflammation ; Laboratories ; Leukocytes, Mononuclear - drug effects ; Leukocytes, Mononuclear - immunology ; Leukocytes, Mononuclear - metabolism ; Life expectancy ; Lymphocytes ; Lymphocytes T ; Medicine ; Medicine and Health Sciences ; Neutrophils ; Polymerase chain reaction ; Preservation ; Regression analysis ; Reverse Transcriptase Polymerase Chain Reaction ; Rodents ; T cells ; Therapy ; Transcriptome - drug effects ; Transcriptome - immunology
É parte de: PloS one, 2017-03, Vol.12 (3), p.e0169868-e0169868
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
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Competing Interests: The authors have declared that no competing interests exist.
Conceptualization: RSD.Data curation: MZ JH.Formal analysis: MZ JH.Funding acquisition: RSD.Methodology: MZ RSD.Project administration: MCAS.Software: JH.Supervision: MCAS.Validation: MZ IKA.Writing – original draft: MZ RSD.Writing – review & editing: JH MCAS.
Descrição: The mechanisms underlying host HIV control hold much promise in the search for a functional HIV cure. We investigated the host genomic signatures in elite controllers or rapid progressors following recent infection and the correlates of immune reconstitution during combination antiretroviral therapy. We characterized the HIV-specific longitudinal host transcriptional response of peripheral blood mononuclear cells from elite controllers, rapid progressors, immune responders and non-responders using a RT-qPCR array in a cohort of recently HIV-infected Brazilian individuals. The elite controllers expressed unique transcripts early in infection that were closely associated with specialized cross-presentation between XCR1+ DCs and antigen-specific CD8+ T cells (XCL1). The natural suppression of HIV was also associated with the highly functional co-expression of cytokines and chemokines (CCL2, TNF and IL-10) concomitant with the maintenance of important anti-inflammatory and anticoagulant properties (Antithrombin III). Immune responders exhibited exclusively upregulated mRNAs possibly related to stem cell mobilization before combination antiretroviral therapy (neutrophil elastase). Our longitudinal approach to gene expression permitted us to discover previously unrecognized determinants that contribute to natural or antiretroviral-mediated HIV-1 immune control.
Editor: United States: Public Library of Science
Idioma: Inglês

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Uniquely altered transcripts are associated with immune preservation in HIV infection

Zanoni, Michelle ; Aventurato, Ítalo Karmann ; Hunter, James ; Sucupira, Maria Cecilia Araripe ; Diaz, Ricardo Sobhie Poli, Guido

United States: Public Library of Science

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