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MYB rearrangement and clinicopathologic characteristics in head and neck adenoid cystic carcinoma

Rettig, Eleni M. ; Tan, Marietta ; Ling, Shizhang ; Yonescu, Raluca ; Bishop, Justin A. ; Fakhry, Carole ; Ha, Patrick K.

The Laryngoscope, 2015-09, Vol.125 (9), p.E292-E299 [Periódico revisado por pares]

United States: Blackwell Publishing Ltd

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Título:
MYB rearrangement and clinicopathologic characteristics in head and neck adenoid cystic carcinoma
Autor: Rettig, Eleni M. ; Tan, Marietta ; Ling, Shizhang ; Yonescu, Raluca ; Bishop, Justin A. ; Fakhry, Carole ; Ha, Patrick K.
Assuntos: Adenoid cystic carcinoma ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Carcinoma, Adenoid Cystic - genetics ; Carcinoma, Adenoid Cystic - mortality ; Carcinoma, Adenoid Cystic - pathology ; Confidence intervals ; Disease-Free Survival ; DNA, Neoplasm - genetics ; Female ; Follow-Up Studies ; Gene Rearrangement - genetics ; Humans ; In Situ Hybridization, Fluorescence ; Male ; Medical prognosis ; Middle Aged ; minor salivary glands ; MYB ; MYB-NFIB fusion gene ; Neoplasm Staging ; Oncogene Proteins, Fusion - genetics ; Retrospective Studies ; salivary gland neoplasms ; Salivary Gland Neoplasms - genetics ; Salivary Gland Neoplasms - mortality ; Salivary Gland Neoplasms - pathology ; survival ; Survival Rate - trends ; Tumors ; Young Adult
É parte de: The Laryngoscope, 2015-09, Vol.125 (9), p.E292-E299
Notas: ark:/67375/WNG-QJD9FSC3-D
istex:DF27A32AAEF14B089DF39AF129AF7F5FCB8012A7
ArticleID:LARY25356
The authors have no other funding, financial relationships, or conflicts of interest to disclose.
Presented at the Combined Sections Meeting of the Triological Society at Coronado Island, California, U.S.A., January 22–24, 2015.
e.m.r.
Research reported in this manuscript was supported by the National Institute of Dental and Craniofacial Research (NIDCR) and NIH grant R01‐ DE023227
j.a.b.
and NIDCR grant 2T32DC000027‐26
The University of Texas M. D. Anderson Cancer Center Career Development Award
p.k.h.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Objectives Salivary gland adenoid cystic carcinoma (ACC) is rare, aggressive, and challenging to treat. Many ACCs have a t(6;9) chromosomal translocation resulting in a MYB‐NFIB fusion gene, but the clinical significance is unclear. The purposes of this study were to describe the clinicopathologic factors impacting survival and to determine the prevalence and clinical significance of MYB‐NFIB fusion. Study Design Case series. Methods Medical records of patients treated for ACC of the head and neck from 1974 to 2011 were reviewed and clinicopathologic data recorded. Fluorescence in situ hybridization (FISH) was used to detect MYB rearrangement in archival tumor tissue as a marker of MYB‐NFIB fusion. Results One hundred fifty‐eight patients were included, with median follow‐up 75.1 months. Median overall survival was 171.5 months (95% confidence interval [CI] = 131.9–191.6), and median disease‐free survival was 112.0 months (95% CI = 88.7–180.4). Advanced stage was associated with decreased overall survival (adjusted ptrend < 0.001), and positive margins were associated with decreased disease‐free survival (adjusted hazard ratio [aHR] = 8.80, 95% CI = 1.25–62.12, P = 0.029). Ninety‐one tumors were evaluable using FISH, and 59 (65%) had evidence of a MYB‐NFIB fusion. MYB‐NFIB positive tumors were more likely than MYB‐NFIB negative tumors to originate in minor salivary glands (adjusted prevalence ratios = 1.51, 95% CI = 1.07–2.12, P = 0.019). MYB‐NFIB tumor status was not significantly associated with disease‐free or overall survival (hazard ratio [HR] = 1.53, 95% CI = 0.77–3.02, P = 0.22 and HR = 0.91, 95% CI = 0.46–1.83, P = 0.80, respectively, for MYB‐NFIB positive compared with MYB‐NFIB negative tumors). Conclusion Stage and margin status were important prognostic factors for ACC. Tumors with evidence of MYB‐NFIB fusion were more likely to originate in minor salivary glands, but MYB‐NFIB tumor status was not significantly associated with prognosis. Level of Evidence 4. Laryngoscope, 125:E292–E299, 2015
Editor: United States: Blackwell Publishing Ltd
Idioma: Inglês

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MYB rearrangement and clinicopathologic characteristics in head and neck adenoid cystic carcinoma

Rettig, Eleni M. ; Tan, Marietta ; Ling, Shizhang ; Yonescu, Raluca ; Bishop, Justin A. ; Fakhry, Carole ; Ha, Patrick K.

United States: Blackwell Publishing Ltd

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