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Global Protein Kinase and Phosphatase Interaction Network in Yeast

Breitkreutz, Ashton ; Choi, Hyungwon ; Sharom, Jeffrey R ; Boucher, Lorrie ; Neduva, Victor ; Larsen, Brett ; Lin, Zhen-Yuan ; Breitkreutz, Bobby-Joe ; Stark, Chris ; Liu, Guomin ; Ahn, Jessica ; Dewar-Darch, Danielle ; Reguly, Teresa ; Tang, Xiaojing ; Almeida, Ricardo ; Qin, Zhaohui Steve ; Pawson, Tony ; Gingras, Anne-Claude ; Nesvizhskii, Alexey I ; Tyers, Mike

Science (American Association for the Advancement of Science), 2010-05, Vol.328 (5981), p.1043-1046 [Periódico revisado por pares]

Washington, DC: American Association for the Advancement of Science

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Título:
Global Protein Kinase and Phosphatase Interaction Network in Yeast
Autor: Breitkreutz, Ashton ; Choi, Hyungwon ; Sharom, Jeffrey R ; Boucher, Lorrie ; Neduva, Victor ; Larsen, Brett ; Lin, Zhen-Yuan ; Breitkreutz, Bobby-Joe ; Stark, Chris ; Liu, Guomin ; Ahn, Jessica ; Dewar-Darch, Danielle ; Reguly, Teresa ; Tang, Xiaojing ; Almeida, Ricardo ; Qin, Zhaohui Steve ; Pawson, Tony ; Gingras, Anne-Claude ; Nesvizhskii, Alexey I ; Tyers, Mike
Assuntos: Binding Sites ; Biological and medical sciences ; Carbon - metabolism ; Cell cycle ; Cell Cycle Proteins - metabolism ; Cellular metabolism ; Datasets ; DNA Damage ; Enzymes ; Fundamental and applied biological sciences. Psychology ; Growth, nutrition, metabolism, transports, enzymes. Molecular biology ; Kinases ; MAP Kinase Signaling System ; Mass Spectrometry ; Metabolic Networks and Pathways ; Microbiology ; Models, Biological ; Mycology ; Nitrogen ; Nitrogen - metabolism ; Phosphatases ; Phosphoprotein Phosphatases - metabolism ; Phosphorylation ; Protein Interaction Mapping ; Protein Kinases - metabolism ; Protein metabolism ; Protein Serine-Threonine Kinases - metabolism ; Protein Subunits - metabolism ; Protein Tyrosine Phosphatases - metabolism ; Proteins ; Proteome ; Proteomes ; Research fellowships ; Research grants ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae - enzymology ; Saccharomyces cerevisiae - metabolism ; Saccharomyces cerevisiae Proteins - metabolism ; Signal Transduction ; Yeast ; Yeasts
É parte de: Science (American Association for the Advancement of Science), 2010-05, Vol.328 (5981), p.1043-1046
Notas: ObjectType-Article-1
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These authors contributed equally to this work.
Descrição: The interactions of protein kinases and phosphatases with their regulatory subunits and substrates underpin cellular regulation. We identified a kinase and phosphatase interaction (KPI) network of 1844 interactions in budding yeast by mass spectrometric analysis of protein complexes. The KPI network contained many dense local regions of interactions that suggested new functions. Notably, the cell cycle phosphatase Cdc14 associated with multiple kinases that revealed roles for Cdc14 in mitogen-activated protein kinase signaling, the DNA damage response, and metabolism, whereas interactions of the target of rapamycin complex 1 (TORC1) uncovered new effector kinases in nitrogen and carbon metabolism. An extensive backbone of kinase-kinase interactions cross-connects the proteome and may serve to coordinate diverse cellular responses.
Editor: Washington, DC: American Association for the Advancement of Science
Idioma: Inglês

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Global Protein Kinase and Phosphatase Interaction Network in Yeast

Washington, DC: American Association for the Advancement of Science

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