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Anti-HCV related to HCV PCR and risk factors analysis in a blood donor population of central Brazil

Martins, R M ; Vanderborght, B O ; Rouzere, C D ; Santana, C L ; Santos, C O ; Mori, D N ; Ferreira, R G ; Yoshida, C F

Revista do Instituto de Medicina Tropical de São Paulo, 1994-12, Vol.36 (6), p.501-506 [Periódico revisado por pares]

Brazil: Instituto de Medicina Tropical

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Título:
Anti-HCV related to HCV PCR and risk factors analysis in a blood donor population of central Brazil
Autor: Martins, R M ; Vanderborght, B O ; Rouzere, C D ; Santana, C L ; Santos, C O ; Mori, D N ; Ferreira, R G ; Yoshida, C F
Assuntos: Adolescent ; Adult ; Blood Donors ; Brazil ; Female ; Hepacivirus - immunology ; Hepatitis Antibodies - blood ; Hepatitis B Antibodies - blood ; Hepatitis B Surface Antigens - blood ; Hepatitis C - immunology ; Hepatitis C - transmission ; Humans ; Male ; Middle Aged ; Polymerase Chain Reaction ; Pregnancy ; Risk Factors ; Transfusion Reaction ; TROPICAL MEDICINE
É parte de: Revista do Instituto de Medicina Tropical de São Paulo, 1994-12, Vol.36 (6), p.501-506
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Data concerning HCV infection in Central Brazil are rare. Upon testing 2,350 voluntary blood donors from this region, we found anti-HCV prevalence rates of 2.2% by a second generation ELISA and 1.4% after confirmation by a line immunoassay. Antibodies against core, NS4, and NS5 antigens of HCV were detected in 81.8%, 72.7%, and 57.5%, respectively, of the positive samples in the line immunoassay. HCV viremia was present in 76.6% of the anti-HCV-positive blood donors. A relation was observed between PCR positivity and serum reactivity in recognizing different HCV antigens in the line immunoassay. The majority of the positive donors had history of previous parenteral exposure. While the combination of ALT > 50 IU/l and anti-HBc positivity do not appear to be good surrogate markers for HCV infection, the use of both ALT anti-HCV tests is indicated in the screening of Brazilian blood donors.
Editor: Brazil: Instituto de Medicina Tropical
Idioma: Inglês;Português

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Anti-HCV related to HCV PCR and risk factors analysis in a blood donor population of central Brazil

Martins, R M ; Vanderborght, B O ; Rouzere, C D ; Santana, C L ; Santos, C O ; Mori, D N ; Ferreira, R G ; Yoshida, C F

Brazil: Instituto de Medicina Tropical

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