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A machine learning framework for the evaluation of myocardial rotation in patients with noncompaction cardiomyopathy

Tavares de Melo, Marcelo Dantas ; Araujo-Filho, Jose de Arimatéia Batista ; Barbosa, José Raimundo ; Rocon, Camila ; Miranda Regis, Carlos Danilo ; Dos Santos Felix, Alex ; Kalil Filho, Roberto ; Bocchi, Edimar Alcides ; Hajjar, Ludhmila Abrahão ; Tabassian, Mahdi ; D'hooge, Jan ; Salemi, Vera Maria Cury Gao, Zhifan

PloS one, 2021-11, Vol.16 (11), p.e0260195-e0260195 [Periódico revisado por pares]

United States: Public Library of Science

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Título:
A machine learning framework for the evaluation of myocardial rotation in patients with noncompaction cardiomyopathy
Autor: Tavares de Melo, Marcelo Dantas ; Araujo-Filho, Jose de Arimatéia Batista ; Barbosa, José Raimundo ; Rocon, Camila ; Miranda Regis, Carlos Danilo ; Dos Santos Felix, Alex ; Kalil Filho, Roberto ; Bocchi, Edimar Alcides ; Hajjar, Ludhmila Abrahão ; Tabassian, Mahdi ; D'hooge, Jan ; Salemi, Vera Maria Cury
Gao, Zhifan
Assuntos: Adult ; Algorithms ; Artificial intelligence ; Biology and Life Sciences ; Cardiology ; Cardiomyopathies - diagnosis ; Cardiomyopathies - pathology ; Cardiomyopathy ; Cardiovascular disease ; Computer and Information Sciences ; Coronary vessels ; Cross-Sectional Studies ; Diagnosis ; Echocardiography ; Engineering and Technology ; Female ; Health aspects ; Heart ; Heart diseases ; Humans ; Learning algorithms ; Machine Learning ; Magnetic resonance ; Magnetic resonance imaging ; Male ; Medicine and Health Sciences ; Middle Aged ; Myocardium ; Myocardium - pathology ; Neural networks ; Neural Networks, Computer ; Research and Analysis Methods ; Rigid structures ; Rotating bodies ; Rotation ; Strain analysis ; Technology application ; Ultrasonic imaging ; Ventricle ; Work stations
É parte de: PloS one, 2021-11, Vol.16 (11), p.e0260195-e0260195
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
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Competing Interests: The authors received no specific funding for this work and the authors have declared that no competing interests exist.
Descrição: Noncompaction cardiomyopathy (NCC) is considered a genetic cardiomyopathy with unknown pathophysiological mechanisms. We propose to evaluate echocardiographic predictors for rigid body rotation (RBR) in NCC using a machine learning (ML) based model. Forty-nine outpatients with NCC diagnosis by echocardiography and magnetic resonance imaging (21 men, 42.8±14.8 years) were included. A comprehensive echocardiogram was performed. The layer-specific strain was analyzed from the apical two-, three, four-chamber views, short axis, and focused right ventricle views using 2D echocardiography (2DE) software. RBR was present in 44.9% of patients, and this group presented increased LV mass indexed (118±43.4 vs. 94.1±27.1g/m2, P = 0.034), LV end-diastolic and end-systolic volumes (P< 0.001), E/e' (12.2±8.68 vs. 7.69±3.13, P = 0.034), and decreased LV ejection fraction (40.7±8.71 vs. 58.9±8.76%, P < 0.001) when compared to patients without RBR. Also, patients with RBR presented a significant decrease of global longitudinal, radial, and circumferential strain. When ML model based on a random forest algorithm and a neural network model was applied, it found that twist, NC/C, torsion, LV ejection fraction, and diastolic dysfunction are the strongest predictors to RBR with accuracy, sensitivity, specificity, area under the curve of 0.93, 0.99, 0.80, and 0.88, respectively. In this study, a random forest algorithm was capable of selecting the best echocardiographic predictors to RBR pattern in NCC patients, which was consistent with worse systolic, diastolic, and myocardium deformation indices. Prospective studies are warranted to evaluate the role of this tool for NCC risk stratification.
Editor: United States: Public Library of Science
Idioma: Inglês

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A machine learning framework for the evaluation of myocardial rotation in patients with noncompaction cardiomyopathy

United States: Public Library of Science

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