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Progression of White Matter Hyperintensities and Incidence of New Lacunes Over a 3-Year Period : The Leukoaraiosis and Disability Study

GOUW, Alida A ; VAN DER FLIER, Wiesje M ; SCHMIDT, Reinhold ; SCHELTENS, Philip ; BARKHOF, Frederik ; FAZEKAS, Franz ; VAN STRAATEN, Elisabeth C. W ; PANTONI, Leonardo ; POGGESI, Anna ; INZITARI, Domenico ; ERKINJUNTTI, Timo ; WAHLUND, Lars O ; WALDEMAR, Gunhild

Stroke (1970), 2008-05, Vol.39 (5), p.1414-1420 [Periódico revisado por pares]

Hagerstown, MD: Lippincott Williams & Wilkins

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Título:
Progression of White Matter Hyperintensities and Incidence of New Lacunes Over a 3-Year Period : The Leukoaraiosis and Disability Study
Autor: GOUW, Alida A ; VAN DER FLIER, Wiesje M ; SCHMIDT, Reinhold ; SCHELTENS, Philip ; BARKHOF, Frederik ; FAZEKAS, Franz ; VAN STRAATEN, Elisabeth C. W ; PANTONI, Leonardo ; POGGESI, Anna ; INZITARI, Domenico ; ERKINJUNTTI, Timo ; WAHLUND, Lars O ; WALDEMAR, Gunhild
Assuntos: 80 and over ; Aged ; Aged, 80 and over ; Basal Ganglia ; Basal Ganglia - blood supply ; Basal Ganglia - pathology ; Basal Ganglia - physiopathology ; Biological and medical sciences ; blood supply ; Brain ; Brain - blood supply ; Brain - pathology ; Brain - physiopathology ; Brain Infarction ; Brain Infarction - epidemiology ; Brain Infarction - pathology ; Brain Infarction - physiopathology ; Brain Ischemia ; Brain Ischemia - epidemiology ; Brain Ischemia - pathology ; Brain Ischemia - physiopathology ; Cardiovascular Diseases ; Cardiovascular Diseases - epidemiology ; Cerebral Arteries ; Cerebral Arteries - pathology ; Cerebral Arteries - physiopathology ; Comorbidity ; Disease Progression ; Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes ; epidemiology ; Female ; Follow-Up Studies ; Frontal Lobe ; Frontal Lobe - blood supply ; Frontal Lobe - pathology ; Frontal Lobe - physiopathology ; Humans ; Hyperlipidemias ; Hyperlipidemias - epidemiology ; Incidence ; Leukoaraiosis ; Leukoaraiosis - epidemiology ; Leukoaraiosis - pathology ; Leukoaraiosis - physiopathology ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Medicin och hälsovetenskap ; Myelinated ; Nerve Fibers ; Nerve Fibers, Myelinated - pathology ; Nervous system (semeiology, syndromes) ; Neurology ; pathology ; physiopathology ; Prevalence ; Psychiatry ; Psykiatri ; Risk Factors ; Time Factors ; Vascular diseases and vascular malformations of the nervous system
É parte de: Stroke (1970), 2008-05, Vol.39 (5), p.1414-1420
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Descrição: We studied the natural course of white matter hyperintensities (WMH) and lacunes, the main MRI representatives of small vessel disease, over time and evaluated possible predictors for their development. Baseline and repeat MRI (3-year follow-up) were collected within the multicenter, multinational Leukoaraiosis and Disability study (n=396). Baseline WMH were scored on MRI by the Fazekas scale and the Scheltens scale. WMH progression was assessed using the modified Rotterdam Progression scale (absence/presence of progression in 9 brain regions). Baseline and new lacunes were counted per region. WMH and lacunes at baseline and vascular risk factors were evaluated as predictors of WMH progression and new lacunes. WMH progressed (mean+/-SD=1.9+/-1.8) mostly in the subcortical white matter, where WMH was also most prevalent at baseline. The majority of new lacunes, which were found in 19% of the subjects (maximum=9), also appeared in the subcortical white matter, mainly of the frontal lobes, whereas most baseline lacunes were located in the basal ganglia. Baseline WMH and lacunes predicted both WMH progression and new lacunes. Furthermore, previous stroke, diabetes, and blood glucose were risk factors for WMH progression. Male sex, hypertension, systolic blood pressure, previous stroke, body mass index, high-density lipoprotein, and triglyceride levels were risk factors for new lacunes. WMH and lacunes progressed over time, predominantly in the subcortical white matter. Progression was observed especially in subjects with considerable WMH and lacunes at baseline. Moreover, the presence of vascular risk factors at baseline predicted WMH progression and new lacunes over a 3-year period.
Editor: Hagerstown, MD: Lippincott Williams & Wilkins
Idioma: Inglês

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Progression of White Matter Hyperintensities and Incidence of New Lacunes Over a 3-Year Period : The Leukoaraiosis and Disability Study

GOUW, Alida A ; VAN DER FLIER, Wiesje M ; SCHMIDT, Reinhold ; SCHELTENS, Philip ; BARKHOF, Frederik ; FAZEKAS, Franz ; VAN STRAATEN, Elisabeth C. W ; PANTONI, Leonardo ; POGGESI, Anna ; INZITARI, Domenico ; ERKINJUNTTI, Timo ; WAHLUND, Lars O ; WALDEMAR, Gunhild

Hagerstown, MD: Lippincott Williams & Wilkins

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