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Copaiba oil suppresses inflammatory cytokines in splenocytes of C57Bl/6 mice induced with experimental autoimmune encephalomyelitis (EAE)

Dias, Débora S ; Fontes, Lívia B A ; Crotti, Antônio E M ; Aarestrup, Beatriz J V ; Aarestrup, Fernando M ; da Silva Filho, Ademar A ; Corrêa, José O A

Molecules (Basel, Switzerland), 2014-08, Vol.19 (8), p.12814-12826 [Periódico revisado por pares]

Switzerland: MDPI AG

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Título:
Copaiba oil suppresses inflammatory cytokines in splenocytes of C57Bl/6 mice induced with experimental autoimmune encephalomyelitis (EAE)
Autor: Dias, Débora S ; Fontes, Lívia B A ; Crotti, Antônio E M ; Aarestrup, Beatriz J V ; Aarestrup, Fernando M ; da Silva Filho, Ademar A ; Corrêa, José O A
Assuntos: Animals ; Anti-Inflammatory Agents - pharmacology ; Autoimmune diseases ; Cells, Cultured ; copaiba oil ; Cytokines ; Cytokines - metabolism ; Drug Evaluation, Preclinical ; Encephalomyelitis ; Encephalomyelitis, Autoimmune, Experimental - drug therapy ; Encephalomyelitis, Autoimmune, Experimental - immunology ; experimental autoimmune encephalomyelitis ; Fabaceae - chemistry ; Female ; Hydrogen Peroxide - metabolism ; immunomodulatory ; Inhibition ; Mice ; Mice, Inbred C57BL ; Multiple sclerosis ; Natural products ; Nitric Oxide - metabolism ; Plant Oils - pharmacology ; Spleen - pathology ; Stimulation ; Tumor necrosis factor-TNF
É parte de: Molecules (Basel, Switzerland), 2014-08, Vol.19 (8), p.12814-12826
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Descrição: Experimental autoimmune encephalomyelitis (EAE) is a murine autoimmune disease used to study multiple sclerosis. We have investigated the immunomodulatory effects of copaiba oil (100, 50 and 25 µg/mL) on NO, H2O2, TNF-α, IFN-γ and IL-17 production in cultured cells from EAE-mice. Copaiba oil (100 µg/mL) inhibited H2O2, NO, IFN-γ TNF-α and IL-17 production spontaneously or after ConA and MOG35-55 stimulation. It is suggested that copaiba oil acts on the mechanism of development of EAE by IFN-γ, IL-17 and TNF-α inhibition, modulating the immune response on both Th1 and Th17 cells.
Editor: Switzerland: MDPI AG
Idioma: Inglês

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Copaiba oil suppresses inflammatory cytokines in splenocytes of C57Bl/6 mice induced with experimental autoimmune encephalomyelitis (EAE)

Dias, Débora S ; Fontes, Lívia B A ; Crotti, Antônio E M ; Aarestrup, Beatriz J V ; Aarestrup, Fernando M ; da Silva Filho, Ademar A ; Corrêa, José O A

Switzerland: MDPI AG

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