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Quantitative Assessment of Aortic Hemodynamics for Varying Left Ventricular Assist Device Outflow Graft Angles and Flow Pulsation

Sahni, Akshita ; McIntyre, Erin E. ; Pal, Jay D. ; Mukherjee, Debanjan

Annals of biomedical engineering, 2023-06, Vol.51 (6), p.1226-1243 [Periódico revisado por pares]

Cham: Springer International Publishing

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Título:
Quantitative Assessment of Aortic Hemodynamics for Varying Left Ventricular Assist Device Outflow Graft Angles and Flow Pulsation
Autor: Sahni, Akshita ; McIntyre, Erin E. ; Pal, Jay D. ; Mukherjee, Debanjan
Assuntos: Anastomosis ; Aorta ; Aorta, Thoracic - physiology ; Aortic arch ; Aortic valve ; Biochemistry ; Biological and Medical Physics ; Biomedical and Life Sciences ; Biomedical Engineering and Bioengineering ; Biomedicine ; Biophysics ; Classical Mechanics ; Complications ; Congestive heart failure ; Coronary vessels ; Flow velocity ; Grafting ; Heart Failure ; Heart valves ; Heart-Assist Devices - adverse effects ; Helicity ; Hemodynamics ; Humans ; Models, Cardiovascular ; Original Article ; Outflow ; Physiology ; Pulsation ; Pulse modulation ; Shear stress ; Systole ; Ventricle ; Ventricular assist devices ; Vorticity ; Wall shear stresses
É parte de: Annals of biomedical engineering, 2023-06, Vol.51 (6), p.1226-1243
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Descrição: Left ventricular assist devices (LVADs) comprise a primary treatment choice for advanced heart failure patients. Treatment with LVAD is commonly associated with complications like stroke and gastro-intestinal (GI) bleeding, which adversely impacts treatment outcomes, and causes fatalities. The etiology and mechanisms of these complications can be linked to the fact that LVAD outflow jet leads to an altered state of hemodynamics in the aorta as compared to baseline flow driven by aortic jet during ventricular systole. Here, we present a framework for quantitative assessment of aortic hemodynamics in LVAD flows realistic human vasculature, with a focus on quantifying the differences between flow driven by LVAD jet and the physiological aortic jet when no LVAD is present. We model hemodynamics in the aortic arch proximal to the LVAD outflow graft, as well as in the abdominal aorta away from the LVAD region. We characterize hemodynamics using quantitative descriptors of flow velocity, stasis, helicity, vorticity and mixing, and wall shear stress. These are used on a set of 27 LVAD scenarios obtained by parametrically varying LVAD outflow graft anastomosis angles, and LVAD flow pulse modulation. Computed descriptors for each of these scenarios are compared against the baseline flow, and a detailed quantitative characterization of the altered state of hemodynamics due to LVAD operation (when compared to baseline aortic flow) is compiled. These are interpreted using a conceptual model for LVAD flow that distinguishes between flow originating from the LVAD outflow jet (and its impingement on the aorta wall), and flow originating from aortic jet during aortic valve opening in normal physiological state.
Editor: Cham: Springer International Publishing
Idioma: Inglês

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Quantitative Assessment of Aortic Hemodynamics for Varying Left Ventricular Assist Device Outflow Graft Angles and Flow Pulsation

Sahni, Akshita ; McIntyre, Erin E. ; Pal, Jay D. ; Mukherjee, Debanjan

Cham: Springer International Publishing

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