Idioma:

A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior

CARLEN, M ; MELETIS, K ; MOORE, C. I ; TSAI, L.-H ; SIEGLE, J. H ; CARDIN, J. A ; FUTAI, K ; VIERLING-CLAASSEN, D ; RÜHLMANN, C ; JONES, S. R ; DEISSEROTH, K ; SHENG, M

Molecular psychiatry, 2012-05, Vol.17 (5), p.537-548 [Periódico revisado por pares]

Basingstoke: Nature Publishing Group

Texto completo disponível

Citações Citado por

Enviar para

Título:
A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior
Autor: CARLEN, M ; MELETIS, K ; MOORE, C. I ; TSAI, L.-H ; SIEGLE, J. H ; CARDIN, J. A ; FUTAI, K ; VIERLING-CLAASSEN, D ; RÜHLMANN, C ; JONES, S. R ; DEISSEROTH, K ; SHENG, M
Assuntos: Albumin ; Animals ; Antagonists ; Antibodies ; Association Learning - drug effects ; Association Learning - physiology ; Associative learning ; Behavior ; Biological and medical sciences ; Brain research ; Brain Waves - drug effects ; Brain Waves - physiology ; Cognitive ability ; Conditioning (Psychology) - drug effects ; Conditioning (Psychology) - physiology ; Excitatory Postsynaptic Potentials - drug effects ; Excitatory Postsynaptic Potentials - physiology ; GABA Antagonists - pharmacology ; GABAergic Neurons - metabolism ; GABAergic Neurons - physiology ; Genetics ; Glutamic acid receptors ; Glutamic acid receptors (ionotropic) ; Habituation ; Health aspects ; Information processing ; Interneurons ; Interneurons - drug effects ; Interneurons - physiology ; Male ; Maze Learning - drug effects ; Maze Learning - physiology ; Medical sciences ; Medicin och hälsovetenskap ; Memory ; Memory, Short-Term - drug effects ; Memory, Short-Term - physiology ; Methyl aspartate ; Mice ; Mice, Transgenic ; N-Methyl-D-aspartic acid receptors ; Neural networks ; Neurosciences ; Neurotransmission ; Optics ; Original ; Oscillations ; Parvalbumin ; Parvalbumins - metabolism ; Photic Stimulation - methods ; Physiological aspects ; Picrotoxin - pharmacology ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors ; Receptors, N-Methyl-D-Aspartate - genetics ; Receptors, N-Methyl-D-Aspartate - physiology ; Rhythm ; Rhythms ; Sensory Gating - drug effects ; Sensory Gating - physiology ; Short term memory ; Stereotyped behavior ; Stereotyped Behavior - drug effects ; Stereotyped Behavior - physiology
É parte de: Molecular psychiatry, 2012-05, Vol.17 (5), p.537-548
Notas: ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Article-2
ObjectType-Feature-1
These authors contributed equally to this work.
Descrição: Synchronous recruitment of fast-spiking (FS) parvalbumin (PV) interneurons generates gamma oscillations, rhythms that emerge during performance of cognitive tasks. Administration of N-methyl-D-aspartate (NMDA) receptor antagonists alters gamma rhythms, and can induce cognitive as well as psychosis-like symptoms in humans. The disruption of NMDA receptor (NMDAR) signaling specifically in FS PV interneurons is therefore hypothesized to give rise to neural network dysfunction that could underlie these symptoms. To address the connection between NMDAR activity, FS PV interneurons, gamma oscillations and behavior, we generated mice lacking NMDAR neurotransmission only in PV cells (PV-Cre/NR1f/f mice). Here, we show that mutant mice exhibit enhanced baseline cortical gamma rhythms, impaired gamma rhythm induction after optogenetic drive of PV interneurons and reduced sensitivity to the effects of NMDAR antagonists on gamma oscillations and stereotypies. Mutant mice show largely normal behaviors except for selective cognitive impairments, including deficits in habituation, working memory and associative learning. Our results provide evidence for the critical role of NMDAR in PV interneurons for expression of normal gamma rhythms and specific cognitive behaviors.
Editor: Basingstoke: Nature Publishing Group
Idioma: Inglês

Links

Voltar para lista de resultados

Realização: Logos de Redes Sociais:

A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior

CARLEN, M ; MELETIS, K ; MOORE, C. I ; TSAI, L.-H ; SIEGLE, J. H ; CARDIN, J. A ; FUTAI, K ; VIERLING-CLAASSEN, D ; RÜHLMANN, C ; JONES, S. R ; DEISSEROTH, K ; SHENG, M

Basingstoke: Nature Publishing Group

Buscando em bases de dados remotas. Favor aguardar.