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Cholesterol metabolism: New functions and therapeutic approaches in cancer

Xu, Huanji ; Zhou, Sheng ; Tang, Qiulin ; Xia, Hongwei ; Bi, Feng

Biochimica et biophysica acta. Reviews on cancer, 2020-08, Vol.1874 (1), p.188394-188394, Article 188394 [Periódico revisado por pares]

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Título:
Cholesterol metabolism: New functions and therapeutic approaches in cancer
Autor: Xu, Huanji ; Zhou, Sheng ; Tang, Qiulin ; Xia, Hongwei ; Bi, Feng
Assuntos: Cancer treatment ; Cholesterol ; Functions ; Metabolism
É parte de: Biochimica et biophysica acta. Reviews on cancer, 2020-08, Vol.1874 (1), p.188394-188394, Article 188394
Notas: ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Descrição: Cholesterol and its metabolites (precursors and derivatives) play an important role in cancer. In recent years, numerous studies have reported the functions of cholesterol metabolism in the regulation of tumor biological processes, especially oncogenic signaling pathways, ferroptosis, and tumor microenvironment. Preclinical studies have over the years indicated the inhibitory effects of blocking cholesterol synthesis and uptake on tumor formation and growth. Besides, some new cholesterol metabolic molecules such as SOAT1, SQLE, and NPC1 have recently emerged as promising drug targets for cancer treatment. Here, we systematically review the roles of cholesterol and its metabolites, and the latest advances in cancer therapy targeting cholesterol metabolism.
Editor: Elsevier B.V
Idioma: Inglês

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