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In vitro activity of Brazilian medicinal plants, naturally occurring naphthoquinones and their analogues, against methicillin-resistant Staphylococcus aureus

Machado, T.B ; Pinto, A.V ; Pinto, M.C.F.R ; Leal, I.C.R ; Silva, M.G ; Amaral, A.C.F ; Kuster, R.M ; Netto-dosSantos, K.R

International journal of antimicrobial agents, 2003-03, Vol.21 (3), p.279-284 [Periódico revisado por pares]

London: Elsevier B.V

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Título:
In vitro activity of Brazilian medicinal plants, naturally occurring naphthoquinones and their analogues, against methicillin-resistant Staphylococcus aureus
Autor: Machado, T.B ; Pinto, A.V ; Pinto, M.C.F.R ; Leal, I.C.R ; Silva, M.G ; Amaral, A.C.F ; Kuster, R.M ; Netto-dosSantos, K.R
Assuntos: Antimicrobial activity ; Biological and medical sciences ; Brazil ; Brazilian medicinal plants ; General pharmacology ; Humans ; Hydrolyzable Tannins ; In Vitro Techniques ; Medical sciences ; Methicillin Resistance ; Microbial Sensitivity Tests ; MRSA strains ; Naphthoquinones - administration & dosage ; Naphthoquinones - chemistry ; Naphthoquinones - isolation & purification ; Naphthoquinones - pharmacology ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Phytotherapy ; Plant Extracts - administration & dosage ; Plant Extracts - pharmacology ; Plants, Medicinal ; Punica granatum ; Punicaceae ; Quinones ; Staphylococcal Infections - drug therapy ; Staphylococcal Infections - microbiology ; Staphylococcus aureus - drug effects ; Staphylococcus aureus - isolation & purification ; Tabebuia ; Tabebuia avellanedae ; Tannins - administration & dosage ; Tannins - chemistry ; Tannins - isolation & purification ; Tannins - pharmacology
É parte de: International journal of antimicrobial agents, 2003-03, Vol.21 (3), p.279-284
Notas: ObjectType-Article-2
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Descrição: Fourteen extracts from Brazilian traditional medicinal plants used to treat infectious diseases were used to look for potential antimicrobial activity against multiresistant bacteria of medical importance. Staphylococcus aureus strains were susceptible to extracts of Punica granatum and Tabebuia avellanedae. The minimum inhibitory concentrations (MICs) of the total extracts and of additional fractions of these plants were determined by employing strains of methicillin-resistant (MRSA) and -sensitive (MSSA) S. aureus, including isolates of the PFGE clone A, which is prevalent in Brazil and two ATCC reference strains. A mixture of ellagitannins isolated from P. granatum and two naphthoquinones isolated from T. avellanedae demonstrated antibacterial activity against all S. aureus strains tested. Semi-synthetic furanonaphthoquinones (FNQs) showed lower MICs than those exhibited by natural occurring naphthoquinones. The results indicate that these natural products can be effective potential candidates for the development of new strategies to treat MRSA infections.
Editor: London: Elsevier B.V
Idioma: Inglês

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In vitro activity of Brazilian medicinal plants, naturally occurring naphthoquinones and their analogues, against methicillin-resistant Staphylococcus aureus

Machado, T.B ; Pinto, A.V ; Pinto, M.C.F.R ; Leal, I.C.R ; Silva, M.G ; Amaral, A.C.F ; Kuster, R.M ; Netto-dosSantos, K.R

London: Elsevier B.V

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